School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
School of Pharmacy, Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia.
Phytother Res. 2018 Mar;32(3):402-412. doi: 10.1002/ptr.5972. Epub 2017 Nov 30.
A systematic review and network-meta analysis (NMA) were performed to test significance of the galactagogue effect of fenugreek administrated to lactating women versus other comparators (i.e., placebo/control/other galactagogues). A pairwise comparison for the treatment effect was carried out to generate the forest plot for the NMA. League tables were generated using treatment effect, weighted mean difference (WMD; 95% confidence interval, CI) for all pairwise comparisons, where WMD > 0 favors the column-defining treatment. Five studies were identified with 122 participants receiving treatment with fenugreek. The NMA results of 4 studies indicated that consumption of fenugreek significantly increased amount of the produced breast milk [11.11, CI 95% 6.77, 15.46] versus placebo. The pairwise comparison revealed that fenugreek was effective as a galactagogue compared to placebo, control, and reference groups WMD 17.79 [CI 11.71, 23.88]. However, the effect of fenugreek was substantially inferior to Coleus amboinicus Lour and palm date. The NMA using pairwise comparison demonstrated the effect of C. amboinicus and palm date in the stimulation of the breast milk production was comparable and superior to all comparators.
进行了系统评价和网络荟萃分析（NMA），以检验在哺乳期妇女中给予葫芦巴与其他对照物（即安慰剂/对照/其他催乳剂）相比催乳效果的显著性。进行了治疗效果的成对比较，以生成 NMA 的森林图。使用治疗效果和所有成对比较的加权均数差（WMD；95%置信区间，CI）生成治疗表，其中 WMD>0 有利于列定义治疗。确定了五项研究，共有 122 名参与者接受葫芦巴治疗。四项研究的 NMA 结果表明，与安慰剂相比，食用葫芦巴可显著增加产奶量[11.11，95%CI 6.77，15.46]。成对比较表明，与安慰剂、对照和参考组相比，葫芦巴作为催乳剂是有效的，WMD 为 17.79[CI 11.71，23.88]。然而，葫芦巴的效果明显低于罗勒和手掌枣。使用成对比较的 NMA 表明，C.amboinicus 和手掌枣在刺激母乳产生方面的效果与所有对照物相当且更优。
