Periodontol 2000. 2018 Feb;76(1):35-42. doi: 10.1111/prd.12158. Epub 2017 Nov 30.
Tooth eruption is characterized by a concert of mechanisms that result in the emergence of teeth in the oral cavity. Genetic variants seem to regulate this process and the formation of a gingival sulcus around the teeth. Interindividual variability in the response to microbial triggers in the sulcus plays an important role in the onset and progression of periodontal diseases. Host genetic variants can influence this variability, affecting the response of the host to the subgingival biofilm. Genetic factors affecting tooth eruption could potentially influence susceptibility to periodontal diseases and, specifically, susceptibility to localized aggressive periodontitis. This review aims to discuss the evidence available for the role of host genetic variants in tooth eruption and to and to give some directions for prospective research in this topic.
牙齿萌出的特征是一系列机制的协同作用，导致牙齿在口腔中出现。遗传变异似乎调节了这个过程和牙齿周围龈沟的形成。龈沟中微生物触发因素的个体间反应变异性在牙周病的发生和进展中起着重要作用。宿主遗传变异可以影响这种变异性，影响宿主对龈下生物膜的反应。影响牙齿萌出的遗传因素可能会影响对牙周病的易感性，特别是对局限性侵袭性牙周炎的易感性。本文旨在讨论宿主遗传变异在牙齿萌出中的作用的现有证据，并为该主题的未来研究提供一些方向。
