Department of Psychiatry, Okehazama Hospital, Toyoake, Aichi, Japan.
Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Asia Pac Psychiatry. 2017 Dec;9(4). doi: 10.1111/appy.12269. Epub 2016 Dec 19.
This study investigated the efficacy of scopolamine (an anticholinergic agent) ointment against clozapine-induced hypersalivation.
The patients enrolled in this study consisted of 10 clozapine-treated schizophrenia patients and 10 healthy adult men. A prospective, randomized, double-blind, crossover, placebo-controlled clinical trial was designed.
A total of 10 patients and 10 healthy adult men completed the study. No significant reduction in the saliva production of the clozapine-treated patients was observed; however, that of the healthy adult men decreased significantly.
Scopolamine ointment was not effective against clozapine-induced hypersalivation. A further study is necessary for confirming its effect.
本研究旨在探讨东莨菪碱（一种抗胆碱能药物）软膏对氯氮平引起的过度流涎的疗效。
本研究纳入了 10 例氯氮平治疗的精神分裂症患者和 10 例健康成年男性。采用前瞻性、随机、双盲、交叉、安慰剂对照临床试验设计。
共有 10 例患者和 10 例健康成年男性完成了研究。氯氮平治疗患者的唾液分泌量没有明显减少，但健康成年男性的唾液分泌量明显减少。
东莨菪碱软膏对氯氮平引起的过度流涎无效。需要进一步研究以确认其效果。
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