Spivak B, Adlersberg S, Rosen L, Gonen N, Mester R, Weizman A
Ness Ziona Mental Health Center, Israel.
Int Clin Psychopharmacol. 1997 Jul;12(4):213-5. doi: 10.1097/00004850-199707000-00005.
The objective of this study was to investigate the efficacy of the anticholinergic agent trihexyphenidyl in the treatment of clozapine-induced hypersalivation. Fourteen chronic schizophrenic patients who exhibited nocturnal hypersalivation during clozapine treatment were coadministered trihexyphenidyl (5-15 mg/day, at bedtime) for 15 days. Salivation was assessed by a single-item 5-point scale. A reduction of 44% in the reported nocturnal hypersalivation was observed after trihexyphenidyl treatment. These results indicate that at least some chronic schizophrenic patients with clozapine-induced nocturnal hypersalivation may benefit from anticholinergic treatment.
本研究的目的是调查抗胆碱能药物苯海索治疗氯氮平引起的唾液分泌过多的疗效。14名在氯氮平治疗期间出现夜间唾液分泌过多的慢性精神分裂症患者联合服用苯海索（5-15毫克/天，睡前服用），持续15天。通过单项5分制量表评估唾液分泌情况。苯海索治疗后，报告的夜间唾液分泌过多减少了44%。这些结果表明，至少一些患有氯氮平引起的夜间唾液分泌过多的慢性精神分裂症患者可能从抗胆碱能治疗中获益。
