Dahl A R
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87185.
Toxicol Lett. 1989 Feb;45(2-3):199-205. doi: 10.1016/0378-4274(89)90010-6.
Hydrogen cyanide is a commonly occurring and highly toxic air pollutant. Inhalation of hydrogen cyanide would expose the nasal tissues to its toxic affects unless a detoxicating mechanism were available. Experiments with rat nasal tissues showed that the cyanide-metabolizing enzyme, rhodanese, is present in high concentrations, particularly in the olfactory region. The olfactory tissues had nearly 7-fold more rhodanese on a per mg mitochondrial protein basis than did the liver. These experiments show that nasal metabolism of cyanide may have an important influence on the toxicity of inhaled cyanide and cyanogenic materials.
氰化氢是一种常见且剧毒的空气污染物。吸入氰化氢会使鼻腔组织暴露于其毒性影响之下，除非存在解毒机制。对大鼠鼻腔组织进行的实验表明，氰化物代谢酶硫氰酸酶大量存在，尤其是在嗅觉区域。以每毫克线粒体蛋白计算，嗅觉组织中的硫氰酸酶含量比肝脏中的含量高近7倍。这些实验表明，鼻腔对氰化物的代谢可能对吸入的氰化物和含氰物质的毒性有重要影响。
