Aminlari M, Vaseghi T, Kargar M A
Department of Biochemistry, School of Veterinary Medicine, Shiraz University, Iran.
Toxicol Appl Pharmacol. 1994 Jan;124(1):67-71. doi: 10.1006/taap.1994.1009.
Studies on the rhodanese activity of respiratory systems of sheep and dog showed that a significant difference exists in the pattern of distribution of this enzyme in different parts of the respiratory system of both species. In sheep, larynx, trachea, bronchiole, and lung contain higher activity than nasal cavity and pharynx. In dog, significantly greater rhodanese activity was found in nasal cavity than in other parts of the respiratory system. In regions with high rhodanese activity the enzyme was more concentrated in the mucosa than in the underneath tissues. These results are discussed in terms of the possible role of rhodanese in cyanide metabolism in respiratory tract and the efficacy of this organ in inhaled cyanide detoxification in these species of animals.
对绵羊和狗呼吸系统中硫氰酸酶活性的研究表明，这两种动物呼吸系统不同部位该酶的分布模式存在显著差异。在绵羊中，喉、气管、细支气管和肺中的活性高于鼻腔和咽。在狗中，鼻腔中的硫氰酸酶活性显著高于呼吸系统的其他部位。在硫氰酸酶活性高的区域，该酶在黏膜中的浓度高于其下方组织。从硫氰酸酶在呼吸道氰化物代谢中的可能作用以及该器官对这些动物吸入氰化物解毒的功效方面对这些结果进行了讨论。
