Lin Yuan-Yu, Chen Ching-Yi, Ding Shih-Torng
Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan.
Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.
PLoS One. 2017 Dec 1;12(12):e0189063. doi: 10.1371/journal.pone.0189063. eCollection 2017.
Hormonal changes that cause metabolic complications are a common problem in postmenopausal women. Adiponectin and osteocalcin are cytokines associated with glucose regulatory and insulin sensitized function in postmenopausal stages. The current study investigated the role of adiponectin signaling and osteocalcin mediated function in glucose metabolism in ovariectomized mice. In a mouse menopausal-related metabolic disorder model, overexpression of adiponectin receptor 1 improved glucose tolerance and caused resistance to body weight increase and decline of serum osteocalcin. Furthermore, adiponectin receptor 1 transgenic ovariectomized mice had higher GPRC6A (the putative osteocalcin receptor) expression in muscle tissue. Immunofluorescence indicated that GPRC6A and adiponectin receptor 1 were co-localized in mouse muscle tissues. The present finding suggested adiponectin receptor 1 can mediate the improvement of glucose metabolism by osteocalcin in ovariectomized mice. Our findings imply the possibility to ameliorate menopause-induced metabolic disorder by GPRC6A and adiponectin signaling.
导致代谢并发症的激素变化是绝经后女性的常见问题。脂联素和骨钙素是与绝经后阶段葡萄糖调节和胰岛素敏感性功能相关的细胞因子。当前研究调查了脂联素信号传导和骨钙素介导的功能在去卵巢小鼠葡萄糖代谢中的作用。在小鼠绝经相关代谢紊乱模型中，脂联素受体1的过表达改善了葡萄糖耐量，并导致对体重增加和血清骨钙素下降的抵抗。此外，脂联素受体1转基因去卵巢小鼠在肌肉组织中具有更高的GPRC6A（假定的骨钙素受体）表达。免疫荧光表明GPRC6A和脂联素受体1在小鼠肌肉组织中共定位。目前的发现表明脂联素受体1可以介导骨钙素对去卵巢小鼠葡萄糖代谢的改善作用。我们的研究结果意味着通过GPRC6A和脂联素信号传导改善绝经诱导的代谢紊乱的可能性。
