Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Cell Metab. 2013 Feb 5;17(2):185-96. doi: 10.1016/j.cmet.2013.01.001. Epub 2013 Jan 24.
Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of Adiponectin receptors AdipoR1 and AdipoR2 has stimulated adiponectin research, revealing pivotal roles for AdipoRs in pleiotropic adiponectin actions, as well as some postreceptor signaling mechanisms. Adiponectin signaling has thus become one of the major research fields in metabolism and clinical medicine. Studies on AdipoRs will further our understanding of the role of adiponectin in obesity-linked diseases and shortened life span and may guide the design of antidiabetic and antiaging drugs with AdipoR as a target.
脂联素是一种脂肪衍生的激素，其减少在肥胖相关疾病中起着核心作用，包括胰岛素抵抗/2 型糖尿病和动脉粥样硬化。脂联素受体 AdipoR1 和 AdipoR2 的克隆刺激了脂联素研究，揭示了 AdipoRs 在脂联素多效作用以及一些受体后信号机制中的关键作用。因此，脂联素信号转导已成为代谢和临床医学的主要研究领域之一。对 AdipoRs 的研究将进一步了解脂联素在肥胖相关疾病和缩短寿命中的作用，并可能指导以 AdipoR 为靶点的抗糖尿病和抗衰老药物的设计。
