与催产素途径基因 ARNT2 多态性相关的情绪识别。
Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.
机构信息
Department of Pharmacology, Institute of Neuroscience and Physiology at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Psychology, Stockholm University, Stockholm, Sweden.
出版信息
Soc Cogn Affect Neurosci. 2018 Feb 1;13(2):173-181. doi: 10.1093/scan/nsx141.
The ability to correctly understand the emotional expression of another person is essential for social relationships and appears to be a partly inherited trait. The neuropeptides oxytocin and vasopressin have been shown to influence this ability as well as face processing in humans. Here, recognition of the emotional content of faces and voices, separately and combined, was investigated in 492 subjects, genotyped for 25 single nucleotide polymorphisms (SNPs) in eight genes encoding proteins important for oxytocin and vasopressin neurotransmission. The SNP rs4778599 in the gene encoding aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), a transcription factor that participates in the development of hypothalamic oxytocin and vasopressin neurons, showed an association that survived correction for multiple testing with emotion recognition of audio-visual stimuli in women (n = 309). This study demonstrates evidence for an association that further expands previous findings of oxytocin and vasopressin involvement in emotion recognition.
正确理解他人情感表达的能力对于社交关系至关重要，而且似乎是部分遗传特征。神经肽催产素和血管升压素已被证明会影响这种能力以及人类对面部的处理。在这里，对 492 名接受了 25 个单核苷酸多态性（SNP）基因分型的受试者进行了研究，这些基因编码了对催产素和血管升压素神经传递很重要的蛋白质。基因编码芳香烃受体核转位蛋白 2（ARNT2）的 rs4778599 与转录因子有关，该转录因子参与了下丘脑催产素和血管升压素神经元的发育，与女性对视听刺激的情感识别存在关联（n=309），该关联在经过多次测试校正后仍然存在。这项研究提供了证据，进一步扩展了先前关于催产素和血管升压素参与情感识别的发现。
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