全基因组认知同理心的荟萃分析：遗传率，以及与性别、神经精神状况和认知的相关性。
Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition.
机构信息
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, UK.
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
出版信息
Mol Psychiatry. 2018 Jun;23(6):1402-1409. doi: 10.1038/mp.2017.122. Epub 2017 Jun 6.
We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, P=1.58 × 10). Common single nucleotide polymorphisms explained 5.8% (95% CI: 4.5%-7.2%; P=1.00 × 10) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.
我们对 88056 名欧洲血统（44574 名女性和 43482 名男性）的 23andMe Inc. 研究志愿者和来自布里斯班纵向双胞胎研究的 1497 名欧洲血统（891 名女性和 606 名男性）研究志愿者进行了认知同理心的全基因组荟萃分析，使用“读心测试”（Eyes Test）。我们证实了女性在 Eyes Test 上具有优势（Cohen's d=0.21，P<2.2×10），并在 3p26.1 发现了一个与女性 Eyes Test 分数相关的基因座（rs7641347，P=1.58×10）。常见的单核苷酸多态性解释了两性总性状方差的 5.8%（95%CI：4.5%-7.2%；P=1.00×10），我们确定了双胞胎遗传率为 28%（95%CI：13%-42%）。最后，我们发现 Eyes Test 与神经性厌食症、开放性（NEO-五因素量表）以及不同的教育程度和认知能力测量之间存在显著的遗传相关性。
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