血小板，各就各位，预备，迁移！

Platelets, On Your Marks, Get Set, Migrate!

机构信息

Max Planck Institute of Immunobiology and Epigenetics, Group Immune Cell Dynamics, Freiburg, Germany; International Max Planck Research School for Molecular and Cellular Biology (IMPRS-MCB), Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.

Max Planck Institute of Immunobiology and Epigenetics, Group Immune Cell Dynamics, Freiburg, Germany.

出版信息

Cell. 2017 Nov 30;171(6):1256-1258. doi: 10.1016/j.cell.2017.11.026.

DOI:10.1016/j.cell.2017.11.026

PMID:29195072

Abstract

The idea that anucleate platelets display autonomous migration has long been viewed with skepticism. Gaertner et al. provide in vivo evidence that platelets undergo active migration at sites of thrombus formation and in inflamed liver sinusoids. Integrin-dependent migration allows platelets to scavenge and bundle fibrin-bound material, including intravascular bacteria.

摘要

长期以来，人们一直对无核血小板具有自主迁移能力的观点持怀疑态度。Gaertner 等人提供了体内证据，表明血小板在血栓形成部位和炎症性肝窦内皮细胞中发生活跃的迁移。整合素依赖性迁移使血小板能够吞噬和聚集纤维蛋白结合的物质，包括血管内细菌。