Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil.
Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil; Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Genética Médica, Campinas, SP, Brazil.
J Pediatr (Rio J). 2019 Jan-Feb;95(1):76-86. doi: 10.1016/j.jped.2017.10.007. Epub 2017 Nov 29.
Volumetric capnography provides the standard CO elimination by the volume expired per respiratory cycle and is a measure to assess pulmonary involvement. Thus, the objective of this study was to evaluate the respiratory dynamics of healthy control subjects and those with cystic fibrosis in a submaximal exercise protocol for six minutes on the treadmill, using volumetric capnography parameters (slope 3 [Slp3], Slp3/tidal volume [Slp3/TV], and slope 2 [Slp2]).
This was a cross-sectional study with 128 subjects (cystic fibrosis, 64 subjects; controls, 64 subjects]. Participants underwent volumetric capnography before, during, and after six minutes on the treadmill. Statistical analysis was performed using the Friedman, Mann-Whitney, and Kruskal-Wallis tests, considering age and sex. An alpha=0.05 was considered.
Six minutes on the treadmill evaluation: in cystic fibrosis, volumetric capnography parameters were different before, during, and after six minutes on the treadmill; the same was observed for the controls, except for Slp2. Regarding age, an Slp3 difference was observed in cystic fibrosis patients regardless of age, at all moments, and in controls for age≥12 years; a difference in Slp3/TV was observed in cystic fibrosis and controls, regardless of age; and an Slp2 difference in the cystic fibrosis, regardless of age. Regarding sex, Slp3 and Slp3/TV differences were observed in cystic fibrosis regardless of sex, and in controls in male participants; an Slp2 difference was observed in the cystic fibrosis and female participants. The analysis between groups (cystic fibrosis and controls) indicated that Slp3 and Slp3/TV has identified the CF, regardless of age and sex, while the Slp2 showed the CF considering age.
Cystic fibrosis showed greater values of the parameters before, during, and after exercise, even when stratified by age and sex, which may indicate ventilation inhomogeneity in the peripheral pathways in the cystic fibrosis.
容积二氧化碳描记法通过每呼吸周期呼出的体积提供标准的 CO 消除，是评估肺受累的一种测量方法。因此，本研究的目的是使用容积二氧化碳描记法参数（斜率 3 [Slp3]、Slp3/潮气量 [Slp3/TV] 和斜率 2 [Slp2]）评估健康对照组和囊性纤维化患者在跑步机上进行六分钟亚最大运动方案时的呼吸动力学。
这是一项横断面研究，共有 128 名受试者（囊性纤维化组 64 名，对照组 64 名）。参与者在跑步机上进行六分钟前、中、后进行容积二氧化碳描记法。使用 Friedman、Mann-Whitney 和 Kruskal-Wallis 检验进行统计分析，考虑年龄和性别。α=0.05。
跑步机评估六分钟：在囊性纤维化中，容积二氧化碳描记法参数在跑步机上进行六分钟前、中、后均不同；对照组也是如此，除了 Slp2。关于年龄，在囊性纤维化患者中，无论年龄大小，在所有时刻，都观察到 Slp3 存在差异，而在对照组中，仅在年龄≥12 岁时观察到 Slp3 差异；在囊性纤维化和对照组中，无论年龄大小，都观察到 Slp3/TV 存在差异；在囊性纤维化中，无论年龄大小，都观察到 Slp2 存在差异。关于性别，在囊性纤维化中，无论性别如何，都观察到 Slp3 和 Slp3/TV 存在差异，而在对照组中，仅在男性参与者中观察到 Slp3 和 Slp3/TV 存在差异；在囊性纤维化和女性参与者中，观察到 Slp2 存在差异。组间分析（囊性纤维化组和对照组）表明，无论年龄和性别如何，Slp3 和 Slp3/TV 均可识别 CF，而 Slp2 仅考虑年龄即可识别 CF。
囊性纤维化患者在运动前、中、后表现出更高的参数值，即使按年龄和性别分层也是如此，这可能表明囊性纤维化患者外周气道存在通气不均。
