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分歧观点对降主动脉瘤治疗的影响。

Impact of Discordant Views in the Management of Descending Thoracic Aortic Aneurysm.

作者信息

Chiu Peter, Sailer Anna-Margaretha, Baiocchi Michael, Goldstone Andrew B, Schaffer Justin M, Trojan Jeff, Fleischmann Dominik, Mitchell R Scott, Miller D Craig, Dake Michael D, Woo Y Joseph, Lee Jason T, Fischbein Michael P

机构信息

Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California.

Department of Radiology, Stanford University, School of Medicine, Stanford, California.

出版信息

Semin Thorac Cardiovasc Surg. 2017;29(3):283-291. doi: 10.1053/j.semtcvs.2017.05.009. Epub 2017 May 29.

DOI:10.1053/j.semtcvs.2017.05.009
PMID:29195571
Abstract

Thoracic endovascular aortic repair has a lower perceived risk than open surgical repair and has become an increasingly popular alternative. Whether general consensus exists regarding candidacy for either operation among open and endovascular specialists is unknown. A retrospective review of isolated descending thoracic aortic aneurysm at our institution between January 2005 and October 2015 was performed, excluding trauma and dissection. Two cardiac surgeons, 2 cardiovascular surgeons, 1 vascular surgeon, and 1 interventional radiologist gave their preference for open vs endovascular repair. Interobserver agreement was assessed with the kappa coefficient. k-means clustering agnostically grouped various patterns of agreement. The mean rating was predicted using least absolute shrinkage and selection operator regression. Negative binomial regression predicted the discrepancy between our panel of raters and the historical operation. Generalized estimating equation modeling was then used to evaluate the association between the extent of discrepancy and the adverse perioperative outcome. There were 77 patients with preoperative imaging studies. Pairwise interobserver agreement was only fair (median weighted kappa 0.270 [interquartile range 0.211-0.404]). Increasing age and proximal neck length predicted an increasing preference for thoracic endovascular aortic repair in our panel; larger proximal neck diameter predicted a general preference for open surgical repair. Increasing proximal neck diameter predicted a larger discrepancy between our panel and the historical operation. Greater discrepancy was associated with adverse outcome. Substantial disagreement existed among our panel, and an exploratory analysis of the effect of increasing discrepancy demonstrated an association with adverse perioperative outcome. An investigation of the effect of a thoracic aortic team with open and endovascular specialists is warranted.

摘要

胸主动脉腔内修复术相比开放性手术修复术,其感知风险更低,已成为越来越受欢迎的替代方案。目前尚不清楚在开放性手术和腔内手术专家中,对于这两种手术的候选资格是否存在普遍共识。我们对2005年1月至2015年10月在本机构进行的孤立性降主动脉瘤进行了回顾性研究,排除创伤和夹层病例。两名心脏外科医生、两名心血管外科医生、一名血管外科医生和一名介入放射科医生表达了他们对开放性手术与腔内修复术的偏好。采用kappa系数评估观察者间的一致性。k均值聚类法对各种一致性模式进行了无监督分组。使用最小绝对收缩和选择算子回归预测平均评分。负二项回归预测了我们的评估小组与历史手术之间的差异。然后使用广义估计方程模型评估差异程度与围手术期不良结局之间的关联。共有77例患者进行了术前影像学检查。观察者间的两两一致性仅为中等(中位数加权kappa为0.270[四分位间距为0.211 - 0.404])。在我们的评估小组中,年龄增加和近端颈部长度增加预示着对胸主动脉腔内修复术的偏好增加;近端颈部直径增大预示着总体上更倾向于开放性手术修复。近端颈部直径增大预示着我们的评估小组与历史手术之间的差异更大。差异越大与不良结局相关。我们的评估小组之间存在很大分歧,对差异增加的影响进行的探索性分析表明其与围手术期不良结局相关。有必要对由开放性手术和腔内手术专家组成的胸主动脉团队产生的影响进行调查。

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