Department of Animal Products and Food Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
The Korean Academy of Science & Technology, Seongnam 13630, Republic of Korea.
Food Res Int. 2017 Dec;102:710-716. doi: 10.1016/j.foodres.2017.09.058. Epub 2017 Sep 22.
The anti-inflammatory effects of boiled pork meat (BPM) and hot water extracts of pork meat (WPM) on splenocyte proliferation and T cell cytokine regulation in BALB/c mice were evaluated. The proliferation of splenocytes in high concentration WPM groups was significantly higher than the control stimulated by LPS and Con A. In the white blood cells, WPM groups had significantly higher counts of lymphocytes and lower counts of neutrophils than the control (p<0.05). The Th1 (IFN-γ, TNF-α, IL-2) and Th2 (IL-4, IL-5, IL-10) cytokine levels in high-concentration WPM groups were higher than those in the control. In addition, TNF-α/IL-10 and IL-2/IL-4 secretions of splenocytes in the high concentration WPM group with LPS or Con A treatment was significantly lower than the control (p<0.05). Therefore, this study suggested that high concentration of WPM had anti-inflammatory effects on the primary splenocyte, which indicating that water extracts of pork meat can enhance the immune system of mice.
本研究旨在评估煮猪肉（BPM）和猪肉热水提取物（WPM）对 BALB/c 小鼠脾细胞增殖和 T 细胞细胞因子调节的抗炎作用。高浓度 WPM 组的脾细胞增殖显著高于 LPS 和 Con A 刺激的对照组。在白细胞中，WPM 组的淋巴细胞计数明显高于对照组，中性粒细胞计数明显低于对照组（p<0.05）。高浓度 WPM 组的 Th1（IFN-γ、TNF-α、IL-2）和 Th2（IL-4、IL-5、IL-10）细胞因子水平均高于对照组。此外，用 LPS 或 Con A 处理的高浓度 WPM 组的 TNF-α/IL-10 和 IL-2/IL-4 分泌明显低于对照组（p<0.05）。因此，本研究表明，高浓度 WPM 对原代脾细胞具有抗炎作用，提示猪肉水提取物可增强小鼠的免疫系统。
