Kusuda Yuina, Takemura Ai, Nakano Masaki, Ishihara Akihiko
Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Laboratory of Functional Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Neurosci Res. 2018 Jul;132:58-62. doi: 10.1016/j.neures.2017.11.008. Epub 2017 Nov 28.
We examined whether exposure to mild hyperbaric oxygen inhibits the decrease of dopaminergic neurons in the substantia nigra of a neurotoxic animal model with Parkinson's disease. Mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride and probenecid twice a week were divided into two groups: mice with mild hyperbaric oxygen and those without. The mice with mild hyperbaric oxygen were exposed to 1317hPa with 45% oxygen for 3h, three times a week. The decrease in dopaminergic neurons of mice with Parkinson's disease was inhibited by 11 weeks of exposure to mild hyperbaric oxygen. We conclude that exposure to mild hyperbaric oxygen is effective in preventing the progression of Parkinson's disease.
我们研究了暴露于轻度高压氧是否能抑制帕金森病神经毒性动物模型黑质中多巴胺能神经元的减少。每周两次注射盐酸1-甲基-4-苯基-1,2,3,6-四氢吡啶和丙磺舒的小鼠被分为两组：轻度高压氧组和非轻度高压氧组。轻度高压氧组小鼠暴露于1317hPa、含45%氧气的环境中3小时，每周三次。暴露于轻度高压氧11周可抑制帕金森病小鼠多巴胺能神经元的减少。我们得出结论，暴露于轻度高压氧对预防帕金森病进展有效。
