轻度高压氧：机制与效应。
Mild hyperbaric oxygen: mechanisms and effects.
机构信息
Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.
出版信息
J Physiol Sci. 2019 Jul;69(4):573-580. doi: 10.1007/s12576-019-00678-5. Epub 2019 May 6.
Abstract
Adequate oxygen supply by exposure to mild hyperbaric oxygen at appropriately high atmospheric pressure (1266-1317 hPa) and increased oxygen concentration (35-40% oxygen) has a possibility of improving the oxidative metabolism in cells and tissues without barotrauma and excessive production of reactive oxygen species. Therefore, metabolic syndrome and lifestyle-related diseases, including type 2 diabetes and hypertension, in rats were inhibited and/or improved by exposure to mild hyperbaric oxygen. It accelerated the growth-induced increase in oxidative capacity of the skeletal muscle in rats and inhibited the age-related decrease in oxidative capacity of the skeletal muscle in mice. A decrease in dopaminergic neurons in the substantia nigra of mice with Parkinson's disease was inhibited by exposure to mild hyperbaric oxygen. This review describes the beneficial effects of exposure to mild hyperbaric oxygen on some metabolic diseases and their perspectives.
摘要
在适当高的大气压力（1266-1317 hPa）和增加的氧气浓度（35-40%氧气）下暴露于适度高压氧中可提供足够的氧气供应，有可能改善细胞和组织中的氧化代谢，而不会产生气压伤和过多的活性氧。因此，代谢综合征和与生活方式相关的疾病，包括 2 型糖尿病和高血压，在大鼠中通过暴露于适度高压氧得到抑制和/或改善。它加速了大鼠因生长引起的骨骼肌氧化能力的增加，并抑制了小鼠与年龄相关的骨骼肌氧化能力的下降。暴露于适度高压氧可抑制帕金森病小鼠中黑质多巴胺能神经元的减少。本综述描述了暴露于适度高压氧对一些代谢性疾病的有益作用及其前景。
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