Hajian-Tilaki Karimollah, Heidari Behzad
Dept of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran.
Dept of Internal Medicine, Ayatollah Rohani hospital, Babol University of Medical Sciences, Babol, Iran.
Diabetes Metab Syndr. 2018 Apr-Jun;12(2):129-134. doi: 10.1016/j.dsx.2017.11.005. Epub 2017 Nov 23.
The objective of this study was to determine the prevalence and the associated factors of metabolically unhealthy in normal-weight and metabolically healthy in obese.
We analyzed the data of a representative sample of 986 participants recruited among adult population of north of Iran. Data were collected regarding demographic characteristics, lifestyle, body mass index, abdominal obesity measures, blood pressure, and lipid profiles. The participants were classified as metabolically healthy obese (MHO) and metabolically unhealthy normal-weight (MUNW). Metabolically unhealthy was defined as the presence of ≥2 non-obese components of metabolic syndrome based on ATP III criteria.
The prevalence rate of MUNW and MHO accounted for 17.2% and 15.1% respectively. Mean age of participants with metabolically unhealthy was significantly greater than metabolically healthy in both normal weight and overweight/obese (P=0.001). The results of multiple logistic regression analysis showed in normal-weight individuals, a significant association of MUNW was found with age group of 50-59 years(OR=3.83, 95%CI: 1.71-8.57) and 60-70 years by OR=4.74(95%CI:1.79-12.54) as compared with age group of 20-29 years. It was also associated with current smoking. While metabolically healthy state in overweight/obese was inversely associated with age 50-59 years by OR=0.26 (95%CI:0.13-0.54) and age 60-70 years by OR=0.15 (95%CI:0.05- 0.39) and higher WC by OR=0.47 (95%CI:0.31-0.72) but positively associated with female-sex by OR=1.74 (95%CI:1.07-2.82).
Aging and smoking are significantly associated with metabolic abnormalities in normal-weight while aging, abdominal obesity negatively and female positively associated with metabolically healthy in obese.
本研究的目的是确定正常体重人群中代谢不健康以及肥胖人群中代谢健康的患病率及其相关因素。
我们分析了从伊朗北部成年人群中招募的986名参与者的代表性样本数据。收集了有关人口统计学特征、生活方式、体重指数、腹部肥胖指标、血压和血脂谱的数据。参与者被分为代谢健康肥胖（MHO）和代谢不健康正常体重（MUNW）。根据ATP III标准，代谢不健康被定义为存在≥2种非肥胖代谢综合征成分。
MUNW和MHO的患病率分别为17.2%和15.1%。在正常体重和超重/肥胖人群中，代谢不健康参与者的平均年龄均显著高于代谢健康者（P = 0.001）。多因素logistic回归分析结果显示，在正常体重个体中，与20 - 29岁年龄组相比，50 - 59岁年龄组（OR = 3.83，95%CI：1.71 - 8.57）和60 - 70岁年龄组（OR = 4.74，95%CI：1.79 - 12.54）的MUNW存在显著关联。它还与当前吸烟有关。而超重/肥胖人群中的代谢健康状态与50 - 59岁年龄组（OR = 0.26，95%CI：0.13 - 0.54）和60 - 70岁年龄组（OR = 0.15，95%CI：0.05 - 0.39）呈负相关，与较高的腰围（OR = 0.47，95%CI：0.31 - 0.72）呈负相关，但与女性呈正相关（OR = 1.74，95%CI：1.07 - 2.82）。
衰老和吸烟与正常体重人群的代谢异常显著相关，而衰老、腹部肥胖与肥胖人群的代谢健康呈负相关，女性则呈正相关。
