伊朗南部沿海地区（PERSIAN 队列研究）代谢不健康肥胖、超重和正常体重的流行情况及其相关危险因素：一项横断面研究。
Prevalence of metabolically unhealthy obesity, overweight, and normal weight and the associated risk factors in a southern coastal region, Iran (the PERSIAN cohort study): a cross-sectional study.
机构信息
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Cellular and Molecular Medicine Department, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
出版信息
BMC Public Health. 2021 Nov 5;21(1):2011. doi: 10.1186/s12889-021-12107-7.
BACKGROUND
Obesity is a substantial risk factor for cardiovascular and metabolic diseases. Epidemiologic studies have shown that some obese and overweight individuals are metabolically healthy. We aimed to determine the prevalence of metabolically unhealthy obesity (MUO), metabolically unhealthy overweight (MUOW), and metabolically unhealthy normal weight (MUNW) in a southern coastal area of Iran, Bandare-Kong Non-Communicable Diseases (BKNCD) Cohort Study.
METHODS
This population-based study included the participants of BKNCD, as part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN). Metabolic health was defined as not fulfilling the metabolic syndrome (MetS) criteria.
RESULTS
Among the 3917 participants in this study with the mean age of 48.29 ± 9.39 years, including 1691 (43.2%) males, the age- and sex-standardized prevalence of MUO, MUOW, and MUNW was 13.9, 16.8, and 6.4%, respectively. Binary logistic regression analysis revealed that the adjusted odds of all metabolically unhealthy states were higher in older age groups, except for MUO whose adjusted odds were lower in the 65-70 age group compared to the 55-64 age group. Illiteracy was significantly correlated with MUOW (adjusted OR: 1.43, 95% CI 1.09-1.87, P = 0.010); however, it was not associated with MUO or MUNW. Higher body mass index (BMI) was significantly correlated with MUNW but it was not associated with MUOW or MUO. Higher waist circumference (WC) was also significantly associated with all metabolically unhealthy states.
CONCLUSION
The age- and sex-standardized prevalence of MUO, MUOW, and MUNW was 13.9, 16.8, and 6.4%, respectively in the current study. Advanced age and higher WC were significantly correlated with all metabolically unhealthy states, while illiteracy and higher BMI were only associated with MUOW and MUNW, respectively. Metabolic health rather than weight loss should be the focus and objective of public prevention programs.
背景
肥胖是心血管疾病和代谢疾病的重要危险因素。流行病学研究表明，一些肥胖和超重的个体代谢健康。本研究旨在确定伊朗南部沿海地区班达尔孔非传染性疾病（BKNCD）队列研究中代谢不健康肥胖（MUO）、代谢不健康超重（MUOW）和代谢健康正常体重（MUNW）的患病率。
方法
本研究为基于人群的研究，纳入了 BKNCD 的参与者，作为伊朗前瞻性流行病学研究（PERSIAN）的一部分。代谢健康定义为不符合代谢综合征（MetS）标准。
结果
本研究共纳入 3917 名参与者，平均年龄为 48.29±9.39 岁，包括 1691 名（43.2%）男性。年龄和性别标准化后，MUO、MUOW 和 MUNW 的患病率分别为 13.9%、16.8%和 6.4%。二元逻辑回归分析显示，除 MUO 外，所有代谢不健康状态的调整后比值比（OR）在年龄较大的年龄组中较高，65-70 岁年龄组的调整后 OR 低于 55-64 岁年龄组。文盲与 MUOW 显著相关（调整 OR：1.43，95%CI 1.09-1.87，P=0.010）；然而，它与 MUO 或 MUNW 无关。较高的体重指数（BMI）与 MUNW 显著相关，但与 MUOW 或 MUO 无关。较高的腰围（WC）也与所有代谢不健康状态显著相关。
结论
在本研究中，MUO、MUOW 和 MUNW 的年龄和性别标准化患病率分别为 13.9%、16.8%和 6.4%。年龄较大和较高的 WC 与所有代谢不健康状态显著相关，而文盲和较高的 BMI 仅与 MUOW 和 MUNW 相关。代谢健康而非减肥应该是公共预防计划的重点和目标。
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