Alsuliman Tamim, Lassoued Kaiss, Belghoul Maifa, Debbache Karima, Choufi Bachra
Service d'Hématologie, Centre Hospitalier de Boulogne-Sur-Mer, Boulogne-Sur-Mer, France.
Service d'Hématologie, Centre Hospitalier Régionale Universitaire de Lille, Lille, France.
Dermatol Ther (Heidelb). 2018 Mar;8(1):165-169. doi: 10.1007/s13555-017-0216-z. Epub 2017 Dec 1.
Pentostatin (2'-deoxycoformycin) and cladribine (2-chlorodeoxyadenosine) are adenosine analogues widely used to treat lymphoid malignancies, mainly hairy cell leukemia (HCL). Oral or parenteral adenosine analogues have been also used as immunomodulatory agents in multiple sclerosis and in acute graft-versus-host disease.
Here, we report the case of a 43-year-old patient with a history of extensive psoriasis who later developed HCL.
The patient had achieved complete remission of both psoriasis and HCL after receiving intravenous infusions of pentostatin. It is worth noting that cladribine has already been reported to treat plaque psoriasis lesions in two patients with HCL and in a third patient with gastric marginal zone B cell lymphoma [1].
We believe that adenosine analogues constitute a promising therapeutic option for moderate to severe psoriasis, especially for severe and refractory psoriasis, as well as for patients with adjacent lymphoid malignancies.
喷司他丁（2'-脱氧助间型霉素）和克拉屈滨（2-氯脱氧腺苷）是腺苷类似物，广泛用于治疗淋巴系统恶性肿瘤，主要是毛细胞白血病（HCL）。口服或胃肠外给予的腺苷类似物也已被用作免疫调节剂，用于治疗多发性硬化症和急性移植物抗宿主病。
在此，我们报告一名43岁有广泛银屑病病史的患者，该患者后来发展为毛细胞白血病。
该患者在接受静脉输注喷司他丁后，银屑病和毛细胞白血病均实现完全缓解值得注意的是，已有报道称克拉屈滨可治疗两名毛细胞白血病患者和一名胃黏膜相关淋巴组织边缘区B细胞淋巴瘤患者 的斑块状银屑病皮损[1]。
我们认为，腺苷类似物是中度至重度银屑病尤其是重度和难治性银屑病以及伴有相关淋巴系统恶性肿瘤患者的一种有前景的治疗选择。
