Woodworth G E, Sears D H, Grove T M, Ruff R H, Kosek P S, Katz R L
Department of Anesthesiology, UCLA School of Medicine 90024.
Anesth Analg. 1989 Mar;68(3):295-7.
A recent study suggested that cimetidine prolongs the duration of action of succinylcholine (SCh). We examined this reported interaction, and investigated whether it is the result of inhibition of plasma cholinesterase (PChE). We also studied the effect of ranitidine on the duration of action of succinylcholine. Thirty patients were randomly assigned to three groups to receive oral cimetidine 300 mg or ranitidine 150 mg or no H2-antagonist the night before surgery and again 1-2 hours prior to induction of anesthesia. Succinylcholine (1.5 mg/kg i.v.) was given to facilitate tracheal intubation after induction of anesthesia; neuromuscular function was monitored by evoked compound electromyogram. Pretreatment blood samples were analyzed for PChE activity. PChE activity and levels of appropriate H2-antagonists were measured in preinduction blood samples. No significant effect of either cimetidine or ranitidine on the duration of action of SCh or PChE activity was demonstrated. We conclude that H2-antagonists administered preoperatively do not prolong the duration of action of succinylcholine or alter PChE activity.
最近的一项研究表明，西咪替丁可延长琥珀酰胆碱（SCh）的作用持续时间。我们对这一报道的相互作用进行了研究，并调查其是否是由于血浆胆碱酯酶（PChE）受到抑制所致。我们还研究了雷尼替丁对琥珀酰胆碱作用持续时间的影响。30例患者被随机分为三组，于手术前一晚及麻醉诱导前1 - 2小时分别口服300 mg西咪替丁、150 mg雷尼替丁或不服用H2拮抗剂。麻醉诱导后静脉注射琥珀酰胆碱（1.5 mg/kg）以利于气管插管；通过诱发复合肌电图监测神经肌肉功能。对预处理的血样进行PChE活性分析。在诱导前血样中测定PChE活性及相应H2拮抗剂的水平。未证实西咪替丁或雷尼替丁对SCh作用持续时间或PChE活性有显著影响。我们得出结论，术前给予H2拮抗剂不会延长琥珀酰胆碱的作用持续时间，也不会改变PChE活性。
