Kambam J R, Franks J J
Department of Anesthesiology, Vanderbilt University Hospital, Nashville, TN 37232.
Anesth Analg. 1988 Jan;67(1):69-70.
Blood samples were drawn from 10 ASA physical status 1 and 2 patients before (baseline) and after the administration of cimetidine to determine the in vivo effect of cimetidine on plasma cholinesterase (PCHE) activity. The in vitro effects of cimetidine at different plasma concentrations were also studied using the same blood samples. PCHE activity in the baseline samples was 432 +/- 4.6 (mean +/- SEM) U/ml, the dibucaine number 82. Administration of oral cimetidine (300 mg) the night before and 2 hours before surgery, failed to have any effect on PCHE activity (no in vivo effect). Plasma cholinesterase activity in the presence of cimetidine in vitro at plasma concentrations of 1.5, 15, 150, and 1500 micrograms/ml was 428, 420, 397, and 177 U/ml, respectively. Thus, in vitro data showed that cimetidine at plasma concentrations (1.5 to 15 micrograms/ml) achieved with clinical doses also has no effect on PCHE activity.
从10例美国麻醉医师协会（ASA）身体状况为1级和2级的患者身上采集血样，分别在给予西咪替丁之前（基线）和之后，以确定西咪替丁对血浆胆碱酯酶（PCHE）活性的体内效应。还使用相同的血样研究了不同血浆浓度的西咪替丁的体外效应。基线样本中的PCHE活性为432±4.6（平均值±标准误）U/ml，地布卡因值为82。术前一晚及术前2小时口服西咪替丁（300mg），对PCHE活性没有任何影响（无体内效应）。在体外，当血浆中西咪替丁浓度分别为1.5、15、150和1500μg/ml时，血浆胆碱酯酶活性分别为428、420、397和177U/ml。因此，体外数据表明，临床剂量所达到的血浆浓度（1.5至15μg/ml）的西咪替丁对PCHE活性也没有影响。
