Center for RNA Research, Institute of Basic Science (IBS) , Seoul 08826, Republic of Korea.
Department of Chemistry, Kwangwoon University , 20 Gwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
Langmuir. 2018 Jan 9;34(1):173-178. doi: 10.1021/acs.langmuir.7b02562. Epub 2017 Dec 15.
Fluorescent Au nanocrystals (AuNCs)-silica hybrid nanocomposite (FLASH) was synthesized by co-condensation of surface-modified AuNCs. Present FLASH nanocomposite exhibited four times the enhanced photoluminescence and photocatalytic activity compared to single nanocrystals. On the basis of these enhanced optical features, we successfully demonstrated in vitro fluorescence bioimaging of introduced FLASH to human cervical cancer cell line (HeLa). Beyond the confirmation of photocatalytic activity from the photodegradation of methylene blue as a model compound, the regional selective photodynamic therapy of HeLa cells under UV irradiation was also presented. Taken together the enhanced optical features and further potential in theranostic applications, we expect that the present FLASH can be a promising tool for nanobiotechnology field.
荧光金纳米晶（AuNCs）-二氧化硅杂化纳米复合材料（FLASH）是通过表面修饰的 AuNCs 的共缩合合成的。与单纳米晶体相比，目前的 FLASH 纳米复合材料表现出增强四倍的光致发光和光催化活性。基于这些增强的光学特性，我们成功地对引入到人类宫颈癌细胞系（HeLa）中的 FLASH 进行了体外荧光生物成像。除了通过模型化合物亚甲基蓝的光降解来确认光催化活性之外，还展示了在 UV 照射下 HeLa 细胞的局部选择性光动力疗法。综上所述，增强的光学特性以及在治疗应用中的进一步潜力，我们预计目前的 FLASH 可以成为纳米生物技术领域的一种有前途的工具。
