Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India.
Biol Trace Elem Res. 2023 Mar;201(3):1026-1050. doi: 10.1007/s12011-022-03226-2. Epub 2022 Apr 25.
Cervical cancer is an aggressive type of cancer affecting women worldwide. Many affected individuals rely on smear tests for the diagnosis, surgery, chemotherapy, or radiation for their treatment. However, due to a broad set of undesired results and side-effects associated with the existing protocols, the search for better diagnostic and therapeutic interventions is a never-ending pursuit. In the purview, the bio-concentration of trace elements (copper, selenium, zinc, iron, arsenic, manganese, and cadmium) is seen to fluctuate during the occurrence of cervical cancer and its progression from pre-cancerous to metastatic nature. Thus, during the occurrence of cervical cancer, the detection of trace elements and their supplementation will prove to be highly advantageous in developing diagnostic tools and therapeutics, respectively. This review provides a detailed overview of cervical cancer, its encouragement by human papillomavirus infections, the mechanism of pathology, and resistance. Majorly, the review emphasizes the less explored role of trace elements, their contribution to the growth and inhibition of cervical cancer. Numerous clinical trials have been listed, thereby providing a comprehensive reference to the exploration of trace elements in the management of cervical cancer.
宫颈癌是一种侵袭性癌症，影响着全球范围内的女性。许多受影响的个体依赖于涂片检查来进行诊断，然后通过手术、化疗或放疗来进行治疗。然而，由于现有方案存在一系列不理想的结果和副作用，因此，寻找更好的诊断和治疗干预措施是一个永无止境的追求。在这方面，微量元素（铜、硒、锌、铁、砷、锰和镉）的生物浓缩在宫颈癌的发生及其从癌前病变到转移性病变的进展过程中会发生波动。因此，在宫颈癌发生时，检测微量元素及其补充将分别有助于开发诊断工具和治疗方法。本综述详细概述了宫颈癌、人乳头瘤病毒感染的促进作用、发病机制和耐药性。主要强调了微量元素的作用研究不足，及其对宫颈癌生长和抑制的影响。列出了许多临床试验，为探索微量元素在宫颈癌管理中的应用提供了全面的参考。
