Bioinformatics Centre, Bose Institute, P-1/12, C.I.T. Scheme VII M, Kolkata 700 054, India.
Bioinformatics Centre, Bose Institute, P-1/12, C.I.T. Scheme VII M, Kolkata 700 054, India; Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur 733134, India.
Genomics. 2018 Sep;110(5):283-290. doi: 10.1016/j.ygeno.2017.11.006. Epub 2017 Dec 2.
Integrating gene expression into protein-protein interaction network (PPIN) leads to the construction of tissue-specific (TS) and housekeeping (HK) sub-networks, with distinctive TS- and HK-hubs. All such hub proteins are divided into multi-interface (MI) hubs and single-interface (SI) hubs, where MI hubs evolve slower than SI hubs. Here we explored the evolutionary rate difference between MI and SI proteins within TS- and HK-PPIN and observed that this difference is present only in TS, but not in HK-class. Next, we explored whether proteins' own properties or its partners' properties are more influential in such evolutionary discrepancy. Statistical analyses revealed that this evolutionary rate correlates negatively with protein's own properties like expression level, miRNA count, conformational diversity and functional properties and with its partners' properties like protein disorder and tissue expression similarity. Moreover, partial correlation and regression analysis revealed that both proteins' and its partners' properties have independent effects on protein evolutionary rate.
将基因表达纳入蛋白质-蛋白质相互作用网络（PPIN）中，可构建组织特异性（TS）和管家（HK）子网，具有独特的 TS 和 HK 枢纽。所有这些枢纽蛋白都分为多接口（MI）枢纽和单接口（SI）枢纽，其中 MI 枢纽的进化速度比 SI 枢纽慢。在这里，我们探索了 TS 和 HK-PPIN 中 MI 和 SI 蛋白之间的进化率差异，结果表明这种差异仅存在于 TS 中，而不存在于 HK 类中。接下来，我们探讨了蛋白质自身的特性或其伴侣的特性在这种进化差异中哪个更具影响力。统计分析表明，这种进化率与蛋白质自身的特性（如表达水平、miRNA 计数、构象多样性和功能特性）及其伴侣的特性（如蛋白质无序性和组织表达相似性）呈负相关。此外，偏相关和回归分析表明，蛋白质及其伴侣的特性对蛋白质进化率都有独立的影响。
