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顺式作用遗传元件对酶组织特异性的调控：来自种间果蝇杂交种的证据。

Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids.

作者信息

Dickinson W J, Carson H L

出版信息

Proc Natl Acad Sci U S A. 1979 Sep;76(9):4559-62. doi: 10.1073/pnas.76.9.4559.

DOI:10.1073/pnas.76.9.4559
PMID:291987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411617/
Abstract

Homologous genes for alcohol dehydrogenase (alcohol:NAD+ oxidoreductase, EC 1.1.1.1) are expressed in qualitatively different patterns during the development of two closely related species of Hawaiian Drosophila. In interspecific hybrids, each parental structural allele is expressed according to the developmental program characteristic of the species from which it is derived. This provides strong evidence for a cis acting control element.

摘要

乙醇脱氢酶（乙醇：NAD⁺氧化还原酶，EC 1.1.1.1）的同源基因在两种亲缘关系密切的夏威夷果蝇物种的发育过程中呈现出质的不同的表达模式。在种间杂种中，每个亲本的结构等位基因都按照其来源物种特有的发育程序进行表达。这为顺式作用控制元件提供了有力证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8cb/411617/8b56e21052cf/pnas00009-0408-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8cb/411617/e6420d901ddd/pnas00009-0408-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8cb/411617/8b56e21052cf/pnas00009-0408-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8cb/411617/e6420d901ddd/pnas00009-0408-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8cb/411617/8b56e21052cf/pnas00009-0408-b.jpg

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Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids.顺式作用遗传元件对酶组织特异性的调控：来自种间果蝇杂交种的证据。
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Genetic Studies on Mutant Enzymes in Maize. III. Control of Gene Action in the Synthesis of Ph 7.5 Esterase.玉米突变酶的遗传学研究。III. 7.5pH值酯酶合成中基因作用的控制
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The genetic control of enzyme activity during differentiation.分化过程中酶活性的遗传控制。
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The electrophoretic behaviour of ten enzyme systems in the larval integument of Drosophila melanogaster.
拟暗果蝇和毛里求斯果蝇雌性杂交种中的交换现象。
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Tissue-specific and substrate-specific detection of aldehyde and pyridoxal oxidase in larval and imaginal tissues of Drosophila melanogaster.黑腹果蝇幼虫和成虫组织中醛氧化酶和吡哆醛氧化酶的组织特异性及底物特异性检测
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Aldehyde oxidases of Drosophila: contributions of several enzymes to observed activity patterns.果蝇的醛氧化酶：几种酶对观察到的活性模式的贡献。
Biochem Genet. 1981 Jun;19(5-6):567-83. doi: 10.1007/BF00484627.
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Genetic control of Adh expression in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶（Adh）表达的遗传控制。
Genetics. 1983 Dec;105(4):921-33. doi: 10.1093/genetics/105.4.921.
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Cytogenetic localization by variation in electrophoretic allozyme phenotype: Drosophila Odh.通过电泳等位酶表型变异进行细胞遗传学定位：果蝇苹果酸脱氢酶
Biochem Genet. 1983 Apr;21(3-4):375-90. doi: 10.1007/BF00499146.
黑腹果蝇幼虫体表十种酶系统的电泳行为
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Evolution at two levels in humans and chimpanzees.人类和黑猩猩两个层面的进化。
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Genetic determination of the beta-galactosidase developmental program in mouse liver.小鼠肝脏中β-半乳糖苷酶发育程序的遗传决定因素
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