黑腹果蝇中乙醇脱氢酶（Adh）表达的遗传控制。
Genetic control of Adh expression in Drosophila melanogaster.
作者信息
Maroni G, Laurie-Ahlberg C C
出版信息
Genetics. 1983 Dec;105(4):921-33. doi: 10.1093/genetics/105.4.921.
Abstract
Natural variants displaying different levels of expression of the gene for alcohol dehydrogenase (Adh) were subjected to genetic mapping experiments. The strains studied carry one of the two common electrophoretic forms of the enzyme. The difference among Adh-fast strains appears to be due to multiple loci with trans-acting effects. Differences among Adh-slow strains are due to modifiers or quantitative sites located very close to the structural gene (less than 0.05 map unit) or part of it. The modifiers detected in the Adhs strains seem to operate only on the structural allele in the cis-position.--A modifier that affects the ratio of ADH levels in larvae and adults was also detected in the Adhs strains. This modifier is also closely linked to Adh and is cis-acting.
摘要
对显示出不同水平乙醇脱氢酶（Adh）基因表达的天然变异体进行了遗传定位实验。所研究的菌株携带该酶的两种常见电泳形式之一。Adh-fast菌株之间的差异似乎是由于具有反式作用的多个基因座所致。Adh-slow菌株之间的差异是由于位于结构基因（小于0.05个图距单位）或其一部分附近的修饰基因或数量位点所致。在Adhs菌株中检测到的修饰基因似乎仅对顺式位置的结构等位基因起作用。——在Adhs菌株中还检测到一个影响幼虫和成虫中ADH水平比例的修饰基因。该修饰基因也与Adh紧密连锁且具有顺式作用。
相似文献
1
Genetic control of Adh expression in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶（Adh）表达的遗传控制。
Genetics. 1983 Dec;105(4):921-33. doi: 10.1093/genetics/105.4.921.
2
Analysis of genetic variation affecting the relative activities of fast and slow ADH dimers in Drosophila melanogaster heterozygotes.影响黑腹果蝇杂合子中快速和慢速乙醇脱氢酶二聚体相对活性的遗传变异分析。
Biochem Genet. 1980 Aug;18(7-8):765-80. doi: 10.1007/BF00484592.
3
Interaction between the Adh and Odh loci in response to ethanol in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶（Adh）和醇脱氢酶（Odh）基因座之间对乙醇的相互作用。
Biochem Genet. 1998 Apr;36(3-4):147-70. doi: 10.1023/a:1018764522536.
4
Drosophila melanogaster alcohol dehydrogenase: an electrophoretic study of the AdhS, AdhF, and AdhUF alleloenzymes.黑腹果蝇乙醇脱氢酶：AdhS、AdhF和AdhUF等位酶的电泳研究
Biochem Genet. 1983 Feb;21(1-2):63-80. doi: 10.1007/BF02395392.
5
Genetic variation in the expression of ADH in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶（ADH）表达的遗传变异。
Genetics. 1982 Jul-Aug;101(3-4):431-46. doi: 10.1093/genetics/101.3-4.431.
6
Restriction map variation in the Adh region of Drosophila.果蝇乙醇脱氢酶（Adh）区域的限制性图谱变异
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5631-5. doi: 10.1073/pnas.79.18.5631.
7
An electrophoretically cryptic alcohol dehydrogenase variant in Drosophila melanogaster. III. Biochemical properties and comparison with common enzyme forms.果蝇中一种电泳隐性醇脱氢酶变体。III. 生化特性及与常见酶形式的比较。
Aust J Biol Sci. 1981;34(5-6):625-37. doi: 10.1071/bi9810625.
8
Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster.黑腹果蝇乙醇脱氢酶基因座的核苷酸多态性
Nature. 1983;304(5925):412-7. doi: 10.1038/304412a0.
9
Variation in amount of enzyme protein in natural populations.自然种群中酶蛋白数量的变异。
Biochem Genet. 1978 Apr;16(3-4):159-70. doi: 10.1007/BF00484075.
10
Genetic basis of the difference in alcohol dehydrogenase expression between Drosophila melanogaster and Drosophila simulans.黑腹果蝇和拟暗果蝇之间乙醇脱氢酶表达差异的遗传基础。
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9674-8. doi: 10.1073/pnas.87.24.9674.
引用本文的文献
1
Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease.Rab11 挽救了亨廷顿舞蹈病果蝇模型中的突触功能障碍和行为缺陷。
Hum Mol Genet. 2012 Jul 1;21(13):2912-22. doi: 10.1093/hmg/dds117. Epub 2012 Mar 30.
2
Frequent gain and loss of functional transcription factor binding sites.功能性转录因子结合位点频繁的获得与丧失。
PLoS Comput Biol. 2007 May;3(5):e99. doi: 10.1371/journal.pcbi.0030099. Epub 2007 Apr 19.
3
Genetic Localization and Action of Regulatory Genes and Elements for Tissue-Specific Expression of alpha-Amylase in DROSOPHILA MELANOGASTER.黑腹果蝇组织特异性α-淀粉酶表达的调控基因和元件的遗传定位与作用。
Genetics. 1986 Dec;114(4):1131-45. doi: 10.1093/genetics/114.4.1131.
4
The influence of whole-arm trisomy on gene expression in Drosophila.整条臂三体对果蝇基因表达的影响。
Genetics. 1988 Jan;118(1):87-101. doi: 10.1093/genetics/118.1.87.
5
Micro-evolution in a wine cellar population: an historical perspective.酒窖菌群中的微进化：历史视角
Genetica. 1993;90(2-3):201-15. doi: 10.1007/BF01435040.
6
Interacting genes control glycerol-3-phosphate dehydrogenase expression in developing cerebellum of the mouse.相互作用的基因控制小鼠发育中小脑的甘油-3-磷酸脱氢酶表达。
Genetics. 1985 May;110(1):123-43. doi: 10.1093/genetics/110.1.123.
7
Naturally occurring quantitative variants of acid phosphatase-1 in Drosophila melanogaster.黑腹果蝇中酸性磷酸酶-1的自然发生的数量变异体。
Biochem Genet. 1985 Jun;23(5-6):465-82. doi: 10.1007/BF00499087.
8
Differences in life history traits between alcohol dehydrogenase genotypes of Drosophila mercatorum: background and maternal genotype effects.梅氏果蝇乙醇脱氢酶基因型之间生活史特征的差异：背景和母本基因型效应
Genetica. 1987 Oct 15;74(2):149-53. doi: 10.1007/BF00055227.
9
The partial characterization of alcohol dehydrogenase null alleles from natural populations of Drosophila melanogaster.黑腹果蝇自然种群中乙醇脱氢酶无效等位基因的部分特征分析
Biochem Genet. 1986 Dec;24(11-12):957-72. doi: 10.1007/BF00554531.
10
Genetic variation for superoxide dismutase level in Drosophila melanogaster.黑腹果蝇中超氧化物歧化酶水平的遗传变异。
Biochem Genet. 1986 Apr;24(3-4):153-68. doi: 10.1007/BF00502785.
本文引用的文献
1
Alcohol Dehydrogenase in Drosophila melanogaster: Isozymes and Genetic Variants.果蝇中的醇脱氢酶：同工酶和遗传变异。
Science. 1965 Jul 2;149(3679):80-2. doi: 10.1126/science.149.3679.80.
2
Genetic variation in the expression of ADH in Drosophila melanogaster.黑腹果蝇中乙醇脱氢酶（ADH）表达的遗传变异。
Genetics. 1982 Jul-Aug;101(3-4):431-46. doi: 10.1093/genetics/101.3-4.431.
3
The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5' end in different developmental stages.黑腹果蝇中乙醇脱氢酶的信使核糖核酸在不同发育阶段，其5'端有所不同。
Cell. 1983 May;33(1):125-33. doi: 10.1016/0092-8674(83)90341-0.
4
Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster.黑腹果蝇乙醇脱氢酶基因座的核苷酸多态性
Nature. 1983;304(5925):412-7. doi: 10.1038/304412a0.
5
Organization of the rosy locus in Drosophila melanogaster: evidence for a control element adjacent to the xanthine dehydrogenase structural element.果蝇中玫瑰色基因座的组织：黄嘌呤脱氢酶结构元件附近存在控制元件的证据。
Genetics. 1976 Oct;84(2):233-55. doi: 10.1093/genetics/84.2.233.
6
Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids.顺式作用遗传元件对酶组织特异性的调控：来自种间果蝇杂交种的证据。
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4559-62. doi: 10.1073/pnas.76.9.4559.
Zotero 插件