Department of Radiology, University of Ulsan, Asan Medical Center, Seoul, South Korea.
Neurosci Lett. 2013 Aug 29;550:64-8. doi: 10.1016/j.neulet.2013.06.050. Epub 2013 Jul 3.
Although Parkinson's disease is a neurodegenerative disease primarily involving basal ganglia and midbrain, the deficit of white matter is also involved during the disease progression. As the diffusion tensor imaging method is sensitive to the microstructural changes, we investigated the microstructural alterations in white matter and deep gray matter in patients with Parkinson's disease. Brain images of 64 patients and sex- and age-matched 64 healthy controls were obtained from a 3T MRI scanner. Tract-based spatial statistics were used to compare the mean diffusivity of the white matter tract between the groups. Voxel-based analysis was used to compare the mean diffusivity of the subcortical gray matter between the groups. There were white matter deficits in the corticofugal tract, cingulum, uncinate fasciculus, crus of fornix or stria terminalis, corpus callosum, external capsule, superior longitudinal fasciculus, posterior thalamic radiation including optic radiation, and the tracts adjacent to the precuneus and supramarginal gyrus, as indicated by higher mean diffusivity in Parkinson's disease patients than in controls. There were also deficits in the left putamen, pallidum, thalamus, and caudate as indicated by higher mean diffusivity in Parkinson's disease patients than in controls. Using diffusion tensor imaging and multi-methods of image analysis, we successfully characterized and visualized brain white matter and deep gray matter areas with microstructural deficits in Parkinson's disease patients.
尽管帕金森病是一种主要涉及基底神经节和中脑的神经退行性疾病，但在疾病进展过程中也涉及到白质的缺失。由于扩散张量成像方法对微观结构变化敏感，我们研究了帕金森病患者的白质和深部灰质的微观结构改变。从 3T MRI 扫描仪获取了 64 名患者和性别及年龄匹配的 64 名健康对照者的脑图像。使用基于束流的空间统计学方法比较了两组之间的白质束平均弥散度。采用基于体素的分析方法比较了两组之间的皮质下灰质的平均弥散度。帕金森病患者的皮质传出束、扣带束、钩束、穹窿脚或终纹、胼胝体、外囊、上纵束、包括视辐射在内的后丘脑辐射以及与楔前叶和缘上回相邻的束流的白质出现了缺失，表现为帕金森病患者的平均弥散度高于对照组。帕金森病患者的左侧壳核、苍白球、丘脑和尾状核的平均弥散度也高于对照组，表明这些部位也存在白质缺失。通过使用扩散张量成像和多方法的图像分析，我们成功地对帕金森病患者的大脑白质和深部灰质区域的微观结构缺失进行了特征化和可视化。
