Dağlı Ülkü, Kalkan İsmail Hakkı
Department of Gastroenterology, Başkent University School of Medicine, Ankara, Turkey
Clinic of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Turk J Gastroenterol. 2017 Dec;28(Suppl 1):S53-S56. doi: 10.5152/tjg.2017.14.
Gastroesophageal reflux disease (GERD) is frequently seen during pregnancy. In the medical treatment of pregnant women with GERD, alginic acid and sucralfate can be used. Calcium- and magnesium-based antacids can also be used, particularly for patients with preeclampsia. In particular, ranitidine -a histamine-2 receptor blocker- is preferred. In the case of non-responsiveness to the abovementioned treatments, proton pump inhibitors (PPIs), except omeprazole, can be given considering the benefit-harm ratio for the mother and fetus after the first trimester. In cases with GERD during the lactation period, drugs having minimum systemic absorption, such as sucralfate and alginic acid, are preferable but there is no data.
胃食管反流病（GERD）在孕期很常见。在GERD孕妇的药物治疗中，可使用海藻酸和硫糖铝。钙和镁基抗酸剂也可使用，尤其是对于先兆子痫患者。特别是雷尼替丁——一种组胺-2受体阻滞剂——是首选。如果对上述治疗无反应，在孕早期后可根据对母亲和胎儿的利弊比考虑给予除奥美拉唑外的质子泵抑制剂（PPI）。在哺乳期患有GERD的情况下，硫糖铝和海藻酸等全身吸收最少的药物是优选的，但尚无相关数据。
