Ruiz-Arguelles A, Presno-Bernal M
Department of Immunology, Laboratorios Clinicos de Puebla, Mexico.
Arthritis Rheum. 1989 Feb;32(2):134-8. doi: 10.1002/anr.1780320204.
A human monoclonal IgM kappa paraprotein with rheumatoid factor (RF) activity was used to elicit antiidiotypic antibodies in rabbits. The antiidiotypic antiserum thus obtained reacted with samples from 40% of 72 rheumatoid arthritis patients, but not with any of the samples from 22 aged control subjects having serum RF. Our findings suggest that, despite the similarities between RF from rheumatoid arthritis patients and that from healthy individuals, the expression of V region genes may be different in healthy subjects and those with the disease.
一种具有类风湿因子（RF）活性的人单克隆IgM κ副蛋白被用于在兔体内诱导抗独特型抗体。由此获得的抗独特型抗血清与72例类风湿关节炎患者中40%的样本发生反应，但与22例患有血清RF的老年对照受试者的任何样本均无反应。我们的研究结果表明，尽管类风湿关节炎患者的RF与健康个体的RF存在相似之处，但健康受试者和患病受试者V区基因的表达可能不同。
