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酒精依赖综合征患者注意力缺陷多动障碍的家庭负担及发病风险

Family Loading and Morbidity Risk of Attention-deficit Hyperactivity Disorder in Patients with Alcohol-dependence Syndrome.

作者信息

Desai Mahesh, Bandawar Mrunal, Kandasamy Arun, Benegal Vivek

机构信息

Department of Psychiatry, KIMS, Hubli, Karnataka, India.

Department of Clinical Neurosciences, NIMHANS, Bengaluru, Karnataka, India.

出版信息

Indian J Psychol Med. 2017 Sep-Oct;39(5):659-662. doi: 10.4103/IJPSYM.IJPSYM_263_17.

DOI:10.4103/IJPSYM.IJPSYM_263_17
PMID:29200564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5688895/
Abstract

BACKGROUND

Attention-deficit hyperactivity disorder (ADHD) and substance-use disorders often co-occur.

AIM

Aim of this study was to look at the family loading of ADHD (in adults and children) in patients with alcohol-dependence syndrome (ADS) along with the estimation of morbidity risk (MR) for developing ADHD.

METHODS

Thirty-five male patients with ADS along with their 369 first-degree relatives (FDRs) - both children and adults - were recruited.

RESULTS

ADHD and residual ADD (ADDRT) were significantly more common in the early-onset (EO) ADS group and their FDR. In ADHD children, high MR (27.27%) for developing EO of ADS was noted.

DISCUSSION

Findings from this study raise an avenue for research in the Indian population about the shared risk between ADS and ADHD.

摘要

背景

注意力缺陷多动障碍(ADHD)与物质使用障碍常同时出现。

目的

本研究旨在观察酒精依赖综合征(ADS)患者中ADHD(成人和儿童)的家族负荷情况,并评估患ADHD的发病风险(MR)。

方法

招募了35名患有ADS的男性患者及其369名一级亲属(FDRs),包括儿童和成人。

结果

ADHD和残留型注意力缺陷障碍(ADDRT)在早发型(EO)ADS组及其FDR中明显更为常见。在患有ADHD的儿童中,发现患早发型ADS的高发病风险(27.27%)。

讨论

本研究结果为印度人群中ADS和ADHD之间共同风险的研究开辟了一条途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55ee/5688895/8c302baa9bdb/IJPsyM-39-659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55ee/5688895/8c302baa9bdb/IJPsyM-39-659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55ee/5688895/8c302baa9bdb/IJPsyM-39-659-g001.jpg

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Indian J Psychol Med. 2017 Jan-Feb;39(1):59-62. doi: 10.4103/0253-7176.198945.
2
Attention-deficit/hyperactivity disorder and risk for substance use disorders in relatives.注意缺陷多动障碍与亲属物质使用障碍风险。
Biol Psychiatry. 2015 May 15;77(10):880-6. doi: 10.1016/j.biopsych.2014.10.006. Epub 2014 Oct 22.
3
The efficacy of atomoxetine as adjunctive treatment for co-morbid substance use disorders and externalizing symptoms.
托莫西汀对共病物质使用障碍和外在症状的辅助治疗效果。
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Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: a meta-analysis and meta-regression analysis.物质使用障碍患者注意缺陷多动障碍的患病率:荟萃分析和荟萃回归分析。
Drug Alcohol Depend. 2012 Apr 1;122(1-2):11-9. doi: 10.1016/j.drugalcdep.2011.12.007. Epub 2011 Dec 30.
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Correlates of alcohol use in adults with ADHD and comorbid alcohol use disorders: exploratory analysis of a placebo-controlled trial of atomoxetine.ADHD 成人酒精使用与共病酒精使用障碍的相关性:阿托西汀安慰剂对照试验的探索性分析。
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The association between attention-deficit/hyperactivity disorder and early-onset alcohol dependence: A retrospective study.注意力缺陷/多动障碍与早发性酒精依赖的相关性:一项回顾性研究。
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