Joob Beuy, Wiwanitkit Viroj
Sanitation 1 Medical Academic Center, Bangkok, Thailand.
Department of Tropical Medicine, Hainan Medical University, Haikou, China.
Indian J Med Paediatr Oncol. 2017 Jul-Sep;38(3):326-327. doi: 10.4103/ijmpo.ijmpo_111_17.
Cholangiocarcinoma is a serious malignancy that is very common in the tropical countries. It is a kind of deadly primary hepatobiliary tumor. There is a wide spectrum of tumors with varying differentiation and malignancy grades. Although it has been known for a long time inmmedicine, there is no clear cut that this deadly cancer is genetic disorder or not. A systemic approach on the pathophysiology and genomics can provide useful information and help better understand the pathogenesis of cholangiocarcinoma.
In this work, a standard bioinformatics physiological genomics analysis of cholangiocarcinoma was performed.
According to this work, there is no identified physiogenomics relationship for the cholangiocarcinoma.
This might imply that the cholangiocarcinoma is directly due to environmental insult. It implies that there should be no specific gene that might contribute to the increased risk in the etiopathogenesis of cholangiocarcinoma.
胆管癌是一种严重的恶性肿瘤，在热带国家非常常见。它是一种致命的原发性肝胆肿瘤。存在一系列具有不同分化程度和恶性等级的肿瘤。尽管在医学领域早有认识，但对于这种致命癌症是否为遗传性疾病尚无明确结论。对病理生理学和基因组学采用系统方法可提供有用信息，并有助于更好地理解胆管癌的发病机制。
在这项研究中，对胆管癌进行了标准的生物信息学生理基因组学分析。
根据这项研究，未发现胆管癌的生理基因组学关系。
这可能意味着胆管癌直接由环境损伤所致。这表明在胆管癌的病因发病机制中，可能不存在导致风险增加的特定基因。
