Wiwanitkit V
Wiwanitkit House, Bangkhae, Bangkok, Thailand; Hainan Medical College, Hainan, China.
Andrologia. 2008 Jun;40(3):158-60. doi: 10.1111/j.1439-0272.2008.00839.x.
Infertility is an important condition in reproductive medicine. According to this work, there is only one identified physiogenomic relationship on chromosome 5 (CAMK4) for male but there are four identified physiogenomic relationships on chromosome 12 (CD9), chromosome 19 (BSG), chromosome 2 (ADCY3) and chromosome 4 (AFP). Although it has been determined for a long time, there is no clear cut genetic difference between male and female infertility. Systemic approach on the pathophysiology and genomics might provide useful information to better understand the pathogenesis of infertility. In this work, physiogenomics analysis for infertility in male and female was performed.
不孕症是生殖医学中的一个重要病症。根据这项研究，在男性中，仅在5号染色体上发现了一种生理基因组关系（钙/钙调蛋白依赖性蛋白激酶4，CAMK4），而在女性中，在12号染色体（CD9）、19号染色体（BSG）、2号染色体（腺苷酸环化酶3，ADCY3）和4号染色体（甲胎蛋白，AFP）上发现了四种生理基因组关系。尽管长期以来人们已经对此有所研究，但男女不孕症之间并没有明显的遗传差异。对病理生理学和基因组学采用系统方法可能会为更好地理解不孕症的发病机制提供有用信息。在这项研究中，对男性和女性不孕症进行了生理基因组学分析。
