and Postprandial Glycemic Activity of Peel Flour.
作者信息
Flores-Fernández José Miguel, Barragán-Álvarez Carla Patricia, Díaz-Martínez Nestor Emmanuel, Villanueva-Rodríguez Socorro, Padilla-Camberos Eduardo
机构信息
División de Ingeniería en Industrias Alimentarias e Ingeniería en Innovación Agrícola Sustentable, Tecnológico de Estudios Superiores de Villa Guerrero, La Finca, Villa Guerrero, Jalisco, Mexico.
Center for Research and Assistance in Technology and Design of Jalisco, Unit of Medical and Pharmaceutical Biotechnology, 44270 Guadalajara, Jalisco, Mexico.
出版信息
Pharmacogn Mag. 2017 Oct-Dec;13(52):613-616. doi: 10.4103/pm.pm_158_17. Epub 2017 Nov 13.
BACKGROUND
Previous studies of spp. peel have shown hypoglycemic and antioxidant activities. has been studied for its therapeutic properties. Diabetes mellitus (DM) is a health problem in Mexico and worldwide, that takes a vital importance due to its high incidence. Recently, scientists have searched natural sources to control the disease.
MATERIALS AND METHODS
In this study, we evaluated the hypoglycemic activity and postprandial glycemic effect of peel flour by glucose adsorption and retardation assays as well as postprandial serum glucose levels using a group of female Balb-c mice, respectively.
RESULTS
peel flour showed a glucose adsorption capacity of 16.58 mM, having a similar effect regarding the positive control. The glucose diffusion in the dialysate was elevated, with a glucose dialysis retardation index of 33.79% in a period of 3 h, showing similar results to positive control. Postprandial serum glucose levels in the animal group treated with peel flour showed a glucose level of 41.4 mg/dL, being this value significantly lower than negative control group and similar to positive control. Toxicity tests showed good tolerance to the dose of 2000 mg/kg.
CONCLUSION
peel flour could act as a source of functional compounds for the control of DM.
SUMMARY
peel flour showed a glucose adsorption capacity similar to the positive controlThe glucose diffusion in the dialysate was elevated, showing similar results to positive controlPostprandial serum glucose levels in the animal group treated with peel flour showed a glucose level significantly lower than negative control group and similar to positive controlToxicity tests showed good tolerance peel flour could act as a source of functional compounds for the control of diabetes mellitus. CIATEJ: Center for Research and Assistance in Technology and Design of Jalisco; DM: Diabetes mellitus; FGC: Final glucose concentration; GDRI: Glucose dialysis retardation index; IGC: Initial glucose concentration; OECD: Organization for Economic Cooperation and Development.
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