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泛素特异性蛋白酶22在癌症中过表达的预后及临床病理意义：一项荟萃分析的证据

Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.

作者信息

Ao Ning, Wang Liang, Liu Yuqin

机构信息

Department of Pathology, Beijing Tiantan Hospital, Capital Medical University.

Department of Pathology, Chinese PLA General Hospital.

出版信息

Onco Targets Ther. 2017 Nov 21;10:5533-5540. doi: 10.2147/OTT.S139458. eCollection 2017.

DOI:10.2147/OTT.S139458
PMID:29200868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5702165/
Abstract

PURPOSE

This meta-analysis study aimed to reveal the prognostic relevance of ubiquitin-specific protease 22 (USP22) expression in patients with cancers.

METHODS

PubMed, Embase, and the Cochrane Library electronic databases were searched for relevant studies published up to April 2017. The prognostic value of USP22 expression was evaluated by hazard ratio with 95% confidence intervals (CIs). Relative risk (RR) with 95% CIs assessed the effects of USP22 expression on clinicopathological parameters. A total of 16 studies of 2,233 Chinese patients were included in the final meta-analysis.

RESULTS

A significant association was found between USP22 overexpression and survival in patients with cancers. The pooled RR indicated that USP22 overexpression was related to histological grade, advanced tumor-node-metastasis stage, positive lymph node metastasis, and distant metastasis.

CONCLUSION

This meta-analysis demonstrated that USP22 could be a novel biomarker for predicting prognosis in patients with cancers in the Chinese population.

摘要

目的

本荟萃分析旨在揭示泛素特异性蛋白酶22（USP22）表达在癌症患者中的预后相关性。

方法

检索PubMed、Embase和Cochrane图书馆电子数据库，查找截至2017年4月发表的相关研究。通过危险比及95%置信区间（CI）评估USP22表达的预后价值。相对危险度（RR）及95%CI评估USP22表达对临床病理参数的影响。最终的荟萃分析纳入了16项针对2233例中国患者的研究。

结果

发现USP22过表达与癌症患者的生存率之间存在显著关联。汇总的RR表明，USP22过表达与组织学分级、肿瘤-淋巴结-转移晚期、阳性淋巴结转移及远处转移相关。

结论

本荟萃分析表明，USP22可能是预测中国人群癌症患者预后的一种新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/dd146dc288aa/ott-10-5533Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/85cc07d80672/ott-10-5533Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/f6031aca2b6c/ott-10-5533Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/2b956b7d8308/ott-10-5533Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/92c8cb760cf2/ott-10-5533Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/dd146dc288aa/ott-10-5533Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/85cc07d80672/ott-10-5533Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/f6031aca2b6c/ott-10-5533Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/2b956b7d8308/ott-10-5533Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/92c8cb760cf2/ott-10-5533Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/685e/5702165/dd146dc288aa/ott-10-5533Fig5.jpg

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LAG3 (CD223) as a cancer immunotherapy target.淋巴细胞活化基因3（CD223）作为癌症免疫治疗靶点。
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Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.USP22和Survivin的表达是肝细胞癌恶性行为的一个指标。
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USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition.USP22通过上调MDMX及随后抑制p53来促进非小细胞肺癌的肿瘤发生。
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