Monda Vincenzo, La Marra Marco, Perrella Raffaella, Caviglia Giorgio, Iavarone Alessandro, Chieffi Sergio, Messina Giovanni, Carotenuto Marco, Monda Marcellino, Messina Antonietta
Department of Experimental Medicine, Section of Human Physiology, University of Campania Luigi Vanvitelli, Naples, Italy.
Neurological and Stroke Unit, CTO Hospital, AORN "Ospedali dei Colli", Naples, Italy.
Diabetes Metab Syndr Obes. 2017 Nov 21;10:473-479. doi: 10.2147/DMSO.S148392. eCollection 2017.
Recent findings showed that obesity represents an additional risk factor to developing brain illness such as cognitive impairments and psychopathological disorders. However, some benefits of overweight in the elderly have been identified and an "obesity paradox" has been shown. Currently, it is still unknown how obesity and brain functioning could be linked, and the process by which body fat independently injures cognitive abilities and psychological well-being remains unclear. To establish the independent role of obesity on cognitive abilities and mental health, clarifying the role played by several factors and understanding their interaction is essential. In this review, we discuss the relationship between obesity and brain illness and underline the role played by confounders and other covariates to determine this link.
最近的研究结果表明，肥胖是引发认知障碍和精神病理障碍等脑部疾病的一个额外风险因素。然而，已发现超重对老年人有一些益处，并出现了“肥胖悖论”。目前，肥胖与大脑功能之间如何关联仍不清楚，而且体内脂肪独立损害认知能力和心理健康的过程也尚不明确。为了确定肥胖对认知能力和心理健康的独立作用，厘清几个因素所起的作用并了解它们之间的相互作用至关重要。在这篇综述中，我们讨论肥胖与脑部疾病之间的关系，并强调混杂因素和其他协变量在确定这种关联中所起的作用。
