Shiraishi T, Hasegawa Y, Itoh H, Nakakuki K
Department of Pathology, Fukui Medical School, Japan.
APMIS. 1989 Feb;97(2):181-4. doi: 10.1111/j.1699-0463.1989.tb00774.x.
We report here on a patient with recurrent sigmoid colon carcinoma. Postmortem examination revealed a fist-sized tumor in the retroperitoneum, invasive to the left ureter obstructing its lumen causing hydronephrosis of the ipsilateral kidney. Histological examination of the kidney showed multiple foci of adenocarcinoma cells on the pelvic surface. Invasion into the underlying tissue was not observed, and there was no tumor in the submucosal tissue of the pelvis or in the parenchyma of the left kidney. Cancer cells on the renal pelvic mucosa showed strong immunoreactivities for CEA and CA 19-9. These findings suggest that the tumor foci in the pelvis are formed by the intraluminal implantation of colon cancer cells detached from the ureteric metastasis. Our case presents the possibility of the implantation of carcinoma cells in the human urinary tract.
我们在此报告一例复发性乙状结肠癌患者。尸检发现腹膜后有一个拳头大小的肿瘤，侵犯左输尿管，阻塞管腔，导致同侧肾积水。肾脏组织学检查显示肾盂表面有多个腺癌细胞灶。未观察到肿瘤侵犯下层组织，盆腔黏膜下层组织或左肾实质内也无肿瘤。肾盂黏膜上的癌细胞对癌胚抗原（CEA）和糖类抗原19-9（CA 19-9）呈强免疫反应性。这些发现表明，盆腔内的肿瘤灶是由输尿管转移灶脱落的结肠癌细胞腔内种植形成的。我们的病例提示了癌细胞在人类泌尿道种植的可能性。
