Dennis Emily L, Rashid Faisal, Jahanshad Neda, Babikian Talin, Mink Richard, Babbitt Christopher, Johnson Jeffrey, Giza Christopher C, Asarnow Robert F, Thompson Paul M
Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Proc IEEE Int Symp Biomed Imaging. 2017;2017:105-108. doi: 10.1109/ISBI.2017.7950479. Epub 2017 Jun 19.
Traumatic brain injury (TBI) is the leading cause of death and disability in children, and can lead to long lasting functional impairment. Many factors influence outcome, but imaging studies examining effects of individual variables are limited by sample size. Roughly 20-40% of hospitalized TBI patients experience seizures, but not all of these patients go on to develop a recurrent seizure disorder. Here we examined differences in structural network connectivity in pediatric patients who had sustained a moderate-severe TBI (msTBI). We compared those who experienced early post-traumatic seizures to those who did not; we found network differences months after seizure activity stopped. We also examined correlations between network measures and a common measure of injury severity, the Glasgow Coma Scale (GCS). The global GCS score did not have a detectable relationship to brain integrity, but sub-scores of the GCS (eyes, motor, verbal) were more closely related to imaging measures.
创伤性脑损伤（TBI）是儿童死亡和残疾的主要原因，并且可导致长期的功能损害。许多因素会影响预后，但研究个体变量影响的影像学研究受样本量限制。约20%-40%的住院TBI患者会发生癫痫，但并非所有这些患者都会发展为复发性癫痫障碍。在此，我们研究了中度至重度创伤性脑损伤（msTBI）患儿的结构网络连通性差异。我们将创伤后早期发生癫痫的患儿与未发生癫痫的患儿进行了比较；我们发现在癫痫活动停止数月后存在网络差异。我们还研究了网络测量值与损伤严重程度的常用指标格拉斯哥昏迷量表（GCS）之间的相关性。GCS总分与脑完整性没有可检测到的关系，但GCS的子分数（眼睛、运动、言语）与影像学测量值的关系更为密切。
