Pilat Nina, Granofszky Nicolas, Wekerle Thomas
Section of Transplantation Immunology, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Curr Transplant Rep. 2017;4(4):253-261. doi: 10.1007/s40472-017-0164-7. Epub 2017 Nov 4.
The mixed chimerism approach is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation and so far the only one that was demonstrated to work in the clinical setting. Regulatory T cells (Tregs) have been shown to improve chimerism induction in experimental animal models. This review summarizes the development of innovative BMT protocols using therapeutic Treg transfer for tolerance induction.
Treg cell therapy promotes BM engraftment in reduced conditioning protocols in both, mice and non-human primates. In mice, transfer of polyclonal recipient Tregs was sufficient to substitute cytotoxic recipient conditioning. Treg therapy prevented chronic rejection of skin and heart allografts related to tissue-specific antigen disparities, in part by promoting intragraft Treg accumulation.
Adoptive Treg transfer is remarkably effective in facilitating BM engraftment in reduced-intensity protocols in mice and non-human primates. Furthermore, it promotes regulatory mechanisms that prevent chronic rejection.
混合嵌合体方法是诱导器官移植中供体特异性耐受的一种极其有效的策略，也是迄今为止唯一在临床环境中被证明有效的方法。调节性T细胞（Tregs）已被证明可改善实验动物模型中的嵌合体诱导。本综述总结了使用治疗性Treg转移诱导耐受的创新骨髓移植方案的进展。
Treg细胞疗法在小鼠和非人灵长类动物的低强度预处理方案中促进骨髓植入。在小鼠中，多克隆受体Tregs的转移足以替代细胞毒性受体预处理。Treg疗法部分通过促进移植内Treg积累，预防了与组织特异性抗原差异相关的皮肤和心脏同种异体移植的慢性排斥反应。
过继性Treg转移在促进小鼠和非人灵长类动物低强度方案中的骨髓植入方面非常有效。此外，它还促进了预防慢性排斥反应的调节机制。
