Ofosu Andrew, Gurakar Ahmet
Department of Medicine, MedStar Harbor Hospital, Maryland, USA.
Department of Gastroenterology and Hepatology, Johns Hopkins School of Medicine, Maryland, USA.
Euroasian J Hepatogastroenterol. 2015 Jan-Jun;5(1):19-25. doi: 10.5005/jp-journals-10018-1123. Epub 2015 Jan 6.
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Multiple treatment modalities for HCC are available, depending on size and number of tumor. Liver transplantation offers the most reasonable option for curative treatment, because it simultaneously removes the burden of the diseased liver. The Milan criteria currently remain the benchmark for the selection of patients with HCC for transplantation. However, there is considerable and promising interest in expanding the eligibility criteria to include the University of California San Francisco criteria. Liver transplantation (LT) has progressed during the past decade. The introduction of living donor LT has provided a means of expanding organ transplant, but with some inherent concerns. Herein, we reviewed the diagnosis and management of HCC with emphasis on the current concepts of liver transplantation for the treatment of HCC.
Ofosu A, Gurakar A. Current Concepts in Hepatocellular Carcinoma and Liver Transplantation: A Review and 2014 Update. Euroasian J Hepato-Gastroenterol 2015;5(1):19-25.
肝细胞癌(HCC)是全球第五大常见癌症。根据肿瘤的大小和数量,有多种针对HCC的治疗方式可供选择。肝移植为根治性治疗提供了最合理的选择,因为它能同时消除患病肝脏的负担。米兰标准目前仍是选择HCC患者进行移植的基准。然而,将入选标准扩大至包括加州大学旧金山分校标准的做法引发了相当大且令人期待的关注。在过去十年中,肝移植(LT)取得了进展。活体供体肝移植的引入为扩大器官移植提供了一种方式,但也存在一些内在问题。在此,我们回顾了HCC的诊断和管理,重点是目前肝移植治疗HCC的相关概念。
奥福苏A,古拉卡尔A。肝细胞癌与肝移植的当前概念:综述及2014年更新。《欧亚肝脏胃肠病学杂志》2015年;5(1):19 - 25。