Shahed Forhad Hossain Md, Rahman Salimur
Department of Medicine, Sadar Hospital, Brahmanbaria, Bangladesh.
Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh.
Euroasian J Hepatogastroenterol. 2016 Jan-Jun;6(1):8-9. doi: 10.5005/jp-journals-10018-1157. Epub 2016 Jul 9.
Ascites is a common complication of chronic liver diseases and is related to the extent of portal hypertension. This study evaluated whether the serum ascites albumin gradient (SAAG) (the difference between the albumin level of serum and of ascitic fluid) is endowed with clinical implications.
This is a prospective study involving 50 patients with cirrhosis of liver with ascites. The SAAG was measured in all patients and its relation with portal hypertensive changes was analyzed.
Based on SAAG values, the patients were divided into three groups: Group 1 - SAAG value 1.1 to 1.49 gm/dL (n = 15); group 2 - SAAG value 1.5 to 1.99 gm/dL (n = 9); and group 3 - SAAG value 2.0 gm/dL (n = 26). In group 1, 14 patients had esophageal varices (93.3%) and 13 had gastropathy (86.6%). In group 2, all 9 patients had esophageal varices (100%), 7 (77.7%) had gastropathy, and 1 (11.1%) had gastric varices. In group 3, all 26 patients had esophageal varices (100%), 24 patients (92.3%) had gastropathy, and 1 patients (3.8%) had gastric varices.
Serum ascites albumin gradient value is weakly related to the extent of portal hypertension in patients with liver cirrhosis and its implication seems to be limited in clinics.
Shahed FHM, Al-Mahtab M, Rahman S. The Evaluation of Serum Ascites Albumin Gradient and Portal Hypertensive changes in Cirrhotic Patients with Ascites. Euroasian J Hepato-Gastroenterol 2016;6(1):8-9.
腹水是慢性肝病的常见并发症，与门静脉高压程度相关。本研究评估血清腹水白蛋白梯度（SAAG）（血清白蛋白水平与腹水白蛋白水平之差）是否具有临床意义。
这是一项前瞻性研究，纳入50例肝硬化腹水患者。对所有患者测量SAAG，并分析其与门静脉高压变化的关系。
根据SAAG值，患者分为三组：第1组-SAAG值1.1至1.49克/分升（n = 15）；第2组-SAAG值1.5至1.99克/分升（n = 9）；第3组-SAAG值2.0克/分升（n = 26）。在第1组中，14例患者有食管静脉曲张（93.3%），13例有胃病（86.6%）。在第2组中，所有9例患者均有食管静脉曲张（100%），7例（77.7%）有胃病，1例（11.1%）有胃静脉曲张。在第3组中，所有26例患者均有食管静脉曲张（100%），24例（92.3%）有胃病，1例（3.8%）有胃静脉曲张。
血清腹水白蛋白梯度值与肝硬化患者门静脉高压程度的相关性较弱，其在临床上的意义似乎有限。
Shahed FHM, Al-Mahtab M, Rahman S. The Evaluation of Serum Ascites Albumin Gradient and Portal Hypertensive changes in Cirrhotic Patients with Ascites. Euroasian J Hepato-Gastroenterol 2016;6(1):8-9.
