肾素-血管紧张素转换酶水平及ACE基因多态性在非酒精性脂肪性肝病患者中的作用

Role of Renin-Angiotensin-converting Enzyme Level and ACE Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease.

作者信息

Tekatas Demet D, Bahcecioglu Ibrahim H, Ispiroglu Murat, Sahin Abdurrahman, Ilhan Necip, Yalniz Mehmet, Demirel Ulvi

机构信息

Department of Gastroenterology, Firat University, Elazig, Turkey.

Department of Biochemistry, Firat University, Elazig, Turkey.

出版信息

Euroasian J Hepatogastroenterol. 2016 Jul-Dec;6(2):137-142. doi: 10.5005/jp-journals-10018-1186. Epub 2016 Dec 1.

DOI:10.5005/jp-journals-10018-1186

PMID:29201746

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5578582/

Abstract

INTRODUCTION

In this study, we aimed to investigate the histological and clinical effect of angiotensin-converting enzyme (ACE) and ACE gene polymorphism in nonalcoholic fatty liver disease (NAFLD) and their roles in the progression of the disease.

MATERIALS AND METHODS

Liver function tests, body mass index, waist circumference, lipid parameters, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), homeostasis model assessment-IR (HOMA-IR), ACE, and ACE gene polymorphism were evaluated in the NAFLD group and control group. The study group was evaluated by dividing the group into four subgroups by ACE gene polymorphism (D/D homozygous, I/I homozygous, D/I heterozygous, I/D heterozygous). Liver biopsies were evaluated according to Brunt Classification.

RESULTS

A total of 31 patients who were diagnosed with NAFLD and 40 healthy individuals were included in the study. The ACE level was found to be 11.69 ± 1.99 in the NAFLD group and 11.52 ± 1.72 in the control group (p = 0.70). There was a negative correlation between ACE levels and HOMA-IR levels (p = 0.008, r= -0.512). Biochemical parameters were not different among ACE gene polimorphism subgroups, except FBG (between D/D, I/D and D/I, I/D; p = 0.02). When the ACE levels were compared in terms of grade and stage, no significant difference was found (for stage and grade p = 0.68). The ACE gene polymorphism subgroups did not differ by histopathologic findings; grade and stage (for grade p = 0.42, for stage p = 0.92).

CONCLUSION

In this study, we could not find a correlation of ACE and ACE gene polymorphism with metabolic risk factors and the disease severity in NAFLD.

HOW TO CITE THIS ARTICLE

Tekatas DD, Bahcecioglu IH, Ispiroglu M, Sahin A, Ilhan N, Yalniz M, Demirel U. Role of Renin-Angiotensin-converting Enzyme Level and ACE Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2016;6(2):137-142.

摘要

引言

在本研究中，我们旨在探讨血管紧张素转换酶（ACE）及其基因多态性在非酒精性脂肪性肝病（NAFLD）中的组织学和临床效应，以及它们在疾病进展中的作用。

材料与方法

对NAFLD组和对照组进行肝功能检查、体重指数、腰围、血脂参数、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、稳态模型评估胰岛素抵抗指数（HOMA-IR）、ACE及ACE基因多态性评估。研究组根据ACE基因多态性分为四个亚组（D/D纯合子、I/I纯合子、D/I杂合子、I/D杂合子）进行评估。肝活检根据布伦特分类法进行评估。

结果

本研究共纳入31例确诊为NAFLD的患者和40例健康个体。NAFLD组ACE水平为11.69±1.99，对照组为11.52±1.72（p = 0.70）。ACE水平与HOMA-IR水平呈负相关（p = 0.008，r = -0.512）。除FBG外（D/D与I/D、D/I与I/D之间；p = 0.02），ACE基因多态性亚组间生化参数无差异。按分级和分期比较ACE水平时，未发现显著差异（分级和分期p = 0.68）。ACE基因多态性亚组在组织病理学结果、分级和分期方面无差异（分级p = 0.42，分期p = 0.92）。

结论

在本研究中，我们未发现ACE及ACE基因多态性与NAFLD代谢危险因素及疾病严重程度之间存在相关性。

如何引用本文

Tekatas DD, Bahcecioglu IH, Ispiroglu M, Sahin A, Ilhan N, Yalniz M, Demirel U. 肾素-血管紧张素转换酶水平及ACE基因多态性在非酒精性脂肪性肝病患者中的作用。《欧亚肝脏胃肠病学杂志》2016；6(2):137 - 142。