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抗生素过度处方:仍是一个主要问题。

Antibiotic overprescribing: Still a major concern.

作者信息

Fiore David C, Fettic Lacy P, Wright Stephanie D, Ferrara Bonnie R

机构信息

Department of Family and Community Medicine, University of Nevada, Reno School of Medicine, Reno, NV, USA. Email:

Department of Family and Community Medicine, University of Nevada, Reno School of Medicine, Reno, NV, USA.

出版信息

J Fam Pract. 2017 Dec;66(12):730-736.

Abstract

Despite universal agreement that antibiotic overprescribing is a problem, the practice continues to vex us. Antibiotic use--whether appropriate or not--has been linked to rising rates of antimicrobial resistance, disruption of the gut microbiome leading to Clostridium difficile infections, allergic reactions, and increased health care costs. And yet, physicians continue to overprescribe this class of medication. A 2016 Centers for Disease Control and Prevention report estimates that at least 30% of antibiotics prescribed in US outpatient settings are unnecessary. Another report cites a slightly higher figure across a variety of health care settings. Pair these findings with the fact that there are currently few new drugs in development to target resistant bacteria, and you have the potential for a post-antibiotic era in which common infections could become lethal. Family practitioners are on the front lines of this battle. Here's what we can do now.

摘要

尽管大家普遍认为抗生素过度处方是个问题,但这种做法仍在困扰着我们。抗生素的使用——无论是否恰当——都与抗菌药物耐药性的上升、导致艰难梭菌感染的肠道微生物群破坏、过敏反应以及医疗保健成本增加有关。然而,医生们仍在继续过度开具这类药物。美国疾病控制与预防中心2016年的一份报告估计,在美国门诊环境中开具的抗生素至少有30%是不必要的。另一份报告给出了各类医疗保健环境中略高的数字。再加上目前针对耐药细菌研发的新药很少这一事实,我们可能会进入一个后抗生素时代,在这个时代,常见感染可能会致命。家庭医生处于这场斗争的前沿。以下是我们现在可以做的。

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