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澳大利亚和新西兰儿童器官捐赠模式。

Patterns of organ donation in children in Australia and New Zealand.

作者信息

Corkery-Lavender Tarryn, Millar Johnny, Cavazzoni Elena, Gelbart Ben

机构信息

The Northern Hospital, Melbourne, VIC, Australia.

Intensive Care Unit, Royal Children's Hospital, Melbourne, VIC, Australia.

出版信息

Crit Care Resusc. 2017 Dec;19(4):296-302.

Abstract

OBJECTIVES

Paediatric organ donation (OD) represents a small proportion of total OD in Australia and New Zealand. Our aim was to describe the patterns of paediatric OD, specifically, the demographic characteristics and donation outcomes over two time periods.

DESIGN

We performed a retrospective study using national OD and intensive care registry data from intensive care units in Australia and New Zealand from 1 January 2000 to 31 December 2015. Data were analysed between two time periods. Paediatric data were compared with adult data.

PARTICIPANTS

Organ donors aged under 16 years in paediatric and mixed adult and paediatric ICUs.

RESULTS

There were 267 paediatric organ donors, representing 5.4% of all donors. The rate of OD as a percentage of ICU deaths was comparable to adults (6.0% v 4.6%; P < 0.001). Over the entire period, donations after brain death totalled 244 (91.4%), and donations after circulatory death (DCDs) totalled 23 (8.6%). DCDs increased from 0.7% to 17% between the time periods (P < 0.001). Children aged under 2 years had a lower rate of donation than the general paediatric cohort (1.2% v 6.0%; P < 0.001).

CONCLUSIONS

Paediatric OD rates have not changed over time but are comparable to adults when expressed as a percentage of ICU deaths. Paediatric DCD has increased significantly over time.

摘要

目的

在澳大利亚和新西兰,儿科器官捐赠(OD)占总器官捐赠的比例较小。我们的目的是描述儿科器官捐赠的模式,具体而言,是两个时间段内的人口统计学特征和捐赠结果。

设计

我们进行了一项回顾性研究,使用了2000年1月1日至2015年12月31日澳大利亚和新西兰重症监护病房的全国器官捐赠和重症监护登记数据。对两个时间段的数据进行了分析。将儿科数据与成人数据进行了比较。

参与者

儿科重症监护病房以及成人与儿科混合重症监护病房中年龄在16岁以下的器官捐赠者。

结果

共有267名儿科器官捐赠者,占所有捐赠者的5.4%。器官捐赠率占重症监护病房死亡人数的百分比与成人相当(6.0%对4.6%;P<0.001)。在整个期间,脑死亡后的捐赠总计244例(91.4%),循环死亡后的捐赠(DCDs)总计23例(8.6%)。两个时间段之间,DCDs从0.7%增加到17%(P<0.001)。2岁以下儿童的捐赠率低于一般儿科队列(1.2%对6.0%;P<0.001)。

结论

儿科器官捐赠率随时间未发生变化,但以重症监护病房死亡人数的百分比表示时与成人相当。儿科DCD随时间显著增加。

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