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在重度抑郁症患者中,中度至重度阻塞性睡眠呼吸暂停综合征的患病率及危险因素:对 703 例患者的观察性和回顾性研究。

Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in major depression: a observational and retrospective study on 703 subjects.

机构信息

Department of Psychiatry and Sleep Laboratory, Erasme Hospital, Université Libre de Bruxelles, ULB, Route de Lennik, 808-1070, Anderlecht, Brussels, Belgium.

出版信息

BMC Pulm Med. 2017 Dec 4;17(1):165. doi: 10.1186/s12890-017-0522-3.

Abstract

BACKGROUND

Several studies have investigated the prevalence and risk factors of depression in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in major depression. The aim of this study was to examine the prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in a large sample of individuals with major depression.

METHODS

Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. An apnea-hypopnea index of ≥15 events per hour was used as cut-off score for moderate to severe obstructive sleep apnea syndrome. Logistic regression analyses were conducted to examine clinical and demographic risk factors of moderate to severe obstructive sleep apnea syndrome in major depression.

RESULTS

The prevalence of moderate to severe obstructive sleep apnea syndrome in major depression is 13.94%. Multivariate logistic regression analysis revealed that male gender, snoring, excessive daytime sleepiness, lower insomnia complaint, presence of metabolic syndrome, age ≥ 50 years, BMI >30 kg/m, ferritin >300 μg/L, CRP >7 mg/L and duration of sleep ≥8 h were significant risk factors of moderate to severe obstructive sleep apnea syndrome in major depression.

CONCLUSION

Moderate to severe obstructive sleep apnea syndrome is a common pathology in major depression. The identification of these different risk factors advances a new perspective for more effective screening of moderate to severe obstructive sleep apnea syndrome in major depression.

摘要

背景

多项研究调查了阻塞性睡眠呼吸暂停综合征患者中抑郁的患病率和危险因素。然而,很少有研究调查过重度抑郁症患者中阻塞性睡眠呼吸暂停综合征的患病率和危险因素。本研究旨在研究大规模重度抑郁症患者中中重度阻塞性睡眠呼吸暂停综合征的患病率和危险因素。

方法

对从 Erasme 医院睡眠实验室研究数据库中招募的 703 名重度抑郁症患者的数据进行了分析。以每小时≥15 次呼吸暂停-低通气指数作为中重度阻塞性睡眠呼吸暂停综合征的截断评分。采用逻辑回归分析方法,对重度抑郁症中重度阻塞性睡眠呼吸暂停综合征的临床和人口统计学危险因素进行了分析。

结果

重度抑郁症中重度阻塞性睡眠呼吸暂停综合征的患病率为 13.94%。多变量逻辑回归分析显示,男性、打鼾、日间嗜睡过多、失眠症状较轻、代谢综合征存在、年龄≥50 岁、BMI>30kg/m、铁蛋白>300μg/L、CRP>7mg/L 和睡眠≥8h 是重度抑郁症中重度阻塞性睡眠呼吸暂停综合征的显著危险因素。

结论

中重度阻塞性睡眠呼吸暂停综合征是重度抑郁症的常见病理表现。这些不同危险因素的确定为更有效地筛查重度抑郁症中的中重度阻塞性睡眠呼吸暂停综合征提供了新的视角。

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