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失眠患者日间过度嗜睡的患病率及相关因素:一项纳入 1311 例患者的研究。

Prevalence and risk factors of excessive daytime sleepiness in insomnia sufferers: A study with 1311 individuals.

机构信息

Erasme Hospital, Université Libre de Bruxelles, ULB, Brussels, Belgium.

Erasme Hospital, Université Libre de Bruxelles, ULB, Brussels, Belgium.

出版信息

J Psychosom Res. 2017 Dec;103:63-69. doi: 10.1016/j.jpsychores.2017.10.004. Epub 2017 Oct 12.

Abstract

BACKGROUND

Several studies have investigated the prevalence and risk factors of excessive daytime sleepiness in the general population. However, few studies have investigated these in the particular subpopulation of insomnia sufferers. Thus, the aim of this study was to examine the prevalence and risk factors of excessive daytime sleepiness in a large sample of insomnia sufferers.

METHODS

Data from 1311 insomnia sufferers with age≥18years and recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. A score>10 on the Epworth scale was used as the cut-off score for excessive daytime sleepiness. Logistic regression analyses were conducted to examine clinical and demographic risk factors of excessive daytime sleepiness in insomnia sufferers.

RESULTS

The prevalence of excessive daytime sleepiness in our sample was 45.61%. Multivariate logistic regression analysis revealed that non-use of Z-drugs, non-use of Trazodone alone or in combination, body mass index≥25 & <30kg/m, body mass index≥30kg/m, age≥18 & <40years, age≥40 & <65years, Beck depression inventory score≥5 & <16, Beck depression inventory score≥16, apnea-hypopnea index≥15/h, and use of selective serotonin reuptake inhibitors were significant risk factors of excessive daytime sleepiness in the subpopulation of insomnia sufferers.

CONCLUSION

Excessive daytime sleepiness is a common complaint for individuals with insomnia. In this subpopulation, most of the risk factors for excessive daytime sleepiness are reversible, which justifies better management of this complaint to avoid its negative consequences.

摘要

背景

已有多项研究调查了普通人群中白天过度嗜睡的患病率和危险因素。然而,很少有研究调查失眠患者这一特定亚群中的这些问题。因此,本研究旨在调查大量失眠患者中白天过度嗜睡的患病率和危险因素。

方法

对来自 Erasme 医院睡眠实验室研究数据库的 1311 名年龄≥18 岁的失眠患者的数据进行了分析。Epworth 量表评分>10 被用作白天过度嗜睡的截断值。采用逻辑回归分析来研究失眠患者中白天过度嗜睡的临床和人口统计学危险因素。

结果

我们样本中白天过度嗜睡的患病率为 45.61%。多变量逻辑回归分析显示,不使用 Z 药物、单独或联合使用曲唑酮、体重指数≥25 & <30kg/m、体重指数≥30kg/m、年龄≥18 & <40 岁、年龄≥40 & <65 岁、贝克抑郁量表评分≥5 & <16、贝克抑郁量表评分≥16、呼吸暂停低通气指数≥15/h 和使用选择性 5-羟色胺再摄取抑制剂是失眠患者亚群中白天过度嗜睡的显著危险因素。

结论

白天过度嗜睡是失眠患者的常见主诉。在这一亚群中,白天过度嗜睡的大多数危险因素是可以逆转的,这证明了更好地管理这一主诉以避免其不良后果是合理的。

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