Cokkinos D V, Salpeas D, Ioannou N E, Christoulas S
Cardiology Department, Tzanio State Hospital, Piraeus, Greece.
Can J Cardiol. 1989 Jan-Feb;5(1):33-6.
Fifteen patients were studied by echocardiography, apexcardiogram and carotid pulse tracings in four ways: basally; on propranolol 40 mg, three times daily; on disopyramide 200 mg single dose, three days after propranolol discontinuation; and on both drugs. The following data were measured: systolic anterior mitral motion slope, systolic anterior mitral distance from the septum, outflow tract diameter, the A wave to the total apexcardiographic excursion ratio, carotid pulse contour and left ventricular ejection time index. Propranolol did not produce any significant changes while disopyramide was much more effective in changing the data in a direction suggesting diminution of left ventricular outflow gradient. The combination of propranolol and disopyramide had the greatest influence. Fourteen patients received the two drugs for 12.3 +/- 4.3 months with improvement of NYHA class.
对15例患者进行了超声心动图、心尖搏动图和颈动脉脉搏描记，共采用四种方式：基础状态；口服普萘洛尔40毫克，每日三次；在停用普萘洛尔三天后单次口服丙吡胺200毫克；以及两种药物联合使用。测量了以下数据：二尖瓣前叶收缩期运动斜率、二尖瓣前叶收缩期距室间隔距离、流出道直径、心尖搏动图A波与总偏移比值、颈动脉脉搏轮廓以及左心室射血时间指数。普萘洛尔未产生任何显著变化，而丙吡胺在改变数据方面更有效，其变化方向提示左心室流出道梯度减小。普萘洛尔与丙吡胺联合使用的影响最大。14例患者接受这两种药物治疗12.3±4.3个月，纽约心脏协会（NYHA）心功能分级得到改善。
