Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai, 200062, China.
Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Sci Rep. 2017 Dec 4;7(1):16868. doi: 10.1038/s41598-017-17069-8.
Long-term headache attacks may cause human brain network reorganization in patients with migraine. In the current study, we calculated the topologic properties of functional networks based on the Brainnetome atlas using graph theory analysis in 29 female migraineurs without aura (MWoA) and in 29 female age-matched healthy controls. Compared with controls, female MWoA exhibited that the network properties altered, and the nodal centralities decreased/increased in some brain areas. In particular, the right posterior insula and the left medial superior occipital gyrus of patients exhibited significantly decreased nodal centrality compared with healthy controls. Furthermore, female MWoA exhibited a disrupted functional network, and notably, the two sub-regions of the right posterior insula exhibited decreased functional connectivity with many other brain regions. The topological metrics of functional networks in female MWoA included alterations in the nodal centrality of brain regions and disrupted connections between pair regions primarily involved in the discrimination of sensory features of pain, pain modulation or processing and sensory integration processing. In addition, the posterior insula decreased the nodal centrality, and exhibited disrupted connectivity with many other brain areas in female migraineurs, which suggests that the posterior insula plays an important role in female migraine pathology.
长期的头痛发作可能导致偏头痛患者的人脑网络重组。在本研究中，我们使用图论分析，根据脑网络图谱，计算了 29 名无先兆偏头痛女性患者（MWoA）和 29 名年龄匹配的女性健康对照者的功能网络的拓扑性质。与对照组相比，女性 MWoA 表现出网络性质的改变，一些脑区的节点中心性降低/增加。特别是，患者右侧后岛和左侧内侧上枕叶的节点中心性明显低于健康对照组。此外，女性 MWoA 表现出功能网络的破坏，特别是右侧后岛的两个亚区与许多其他脑区的功能连接明显减少。女性 MWoA 功能网络的拓扑度量包括脑区节点中心性的改变，以及主要涉及疼痛感觉特征、疼痛调节或处理以及感觉整合处理的区分的对区域之间连接的破坏。此外，后岛的节点中心性降低，并与许多其他脑区的连接中断，这表明后岛在女性偏头痛病理中起着重要作用。
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