Silva Natália de Oliveira, Maciel Nicoly Machado, Nather Júlio César, Carvalho Gabriela Ferreira, Pinheiro Carina Ferreira, Bigal Marcelo Eduardo, Santos Antônio Carlos Dos, Bevilaqua-Grossi Debora, Dach Fabiola
Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14015-010, SP, Brazil.
Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14015-010, SP, Brazil.
Diagnostics (Basel). 2023 Feb 20;13(4):799. doi: 10.3390/diagnostics13040799.
Repeated migraine attacks and aura could independently cause structural changes in the central nervous system. Our research aims to study the correlation of migraine type, attack frequency, and other clinical variables with the presence, volume and localization of white matter lesions (WML), in a controlled study.
Sixty volunteers from a tertiary headache center were selected and divided equally into four groups: episodic migraine without aura (MoA), episodic migraine with aura (MA), chronic migraine (CM) and controls (CG). Voxel-based morphometry techniques were used to analyze WML.
There were no differences in WML variables between groups. There was a positive correlation between age and the number and total volume of WMLs, which persisted in the comparison categorized by size and brain lobe. Disease duration was positively correlated with the number and total volume of WML, and when controlled by age, the correlation maintained significance only for the insular lobe. Aura frequency was associated with frontal and temporal lobe WMLs. There was no statistically significant correlation between WML and other clinical variables.
Migraine overall is not a risk factor for WML. Aura frequency is, however, associated with temporal WML. Disease duration, in adjusted analyses that account for age, is associated with insular WML.
反复的偏头痛发作和先兆可能独立导致中枢神经系统的结构变化。我们的研究旨在通过一项对照研究，探讨偏头痛类型、发作频率及其他临床变量与白质病变（WML）的存在、体积和定位之间的相关性。
从一家三级头痛中心选取60名志愿者，平均分为四组：无先兆发作性偏头痛（MoA）、有先兆发作性偏头痛（MA）、慢性偏头痛（CM）和对照组（CG）。采用基于体素的形态测量技术分析WML。
各组之间WML变量无差异。年龄与WML的数量和总体积呈正相关，在按大小和脑叶分类的比较中这种相关性持续存在。病程与WML的数量和总体积呈正相关，在控制年龄后，这种相关性仅在岛叶中保持显著。先兆发作频率与额叶和颞叶WML相关。WML与其他临床变量之间无统计学显著相关性。
总体而言，偏头痛不是WML的危险因素。然而，先兆发作频率与颞叶WML相关。在考虑年龄的校正分析中，病程与岛叶WML相关。
