Weinberger I, Fuchs J, Rotenberg Z, Davidson E, Harel D, Agmon J
Department of Medicine A, Beilinson Medical Center, Petah Tikva, Israel.
Clin Chem. 1989 Mar;35(3):414-6.
Peak activity of creatine kinase (CK; EC 2.7.3.2) and its decline were determined in 380 patients with acute myocardial infarction (AMI) whose CK values had peaked after admission to the hospital. During hospitalization, 26 patients either died (14 patients) or experienced nonfatal re-infarction (12 patients). In 22 of these 26 patients CK activity decreased by less than 50% within 48 h after the peak value was measured. In all patients who did not die or develop re-infarction, CK activity decreased by greater than 50% during the 48 h after the peak. Evidently the rate of decline of CK (i.e., whether more than or less than 50%) from its peak value during the 48 h after AMI may be helpful in assessing which patients are at high risk for developing re-infarction or dying.
在380例入院后肌酸激酶（CK；EC 2.7.3.2）达到峰值的急性心肌梗死（AMI）患者中，测定了CK的峰值活性及其下降情况。住院期间，26例患者死亡（14例）或发生非致命性再梗死（12例）。在这26例患者中，有22例在测量峰值后48小时内CK活性下降不到50%。在所有未死亡或未发生再梗死的患者中，CK活性在峰值后的48小时内下降超过50%。显然，急性心肌梗死后48小时内CK从峰值下降的速率（即是否超过或低于50%）可能有助于评估哪些患者发生再梗死或死亡的风险较高。
