McMullen Kyle P, Chalmers Jeffrey J, Lang Jas C, Kumar Pawan, Jatana Kris R
Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, OH, USA.
William G. Lowrie Department of Chemical and Biomolecular Engineering, Ohio State University, Columbus, OH, USA.
World J Otorhinolaryngol Head Neck Surg. 2016 Jul 21;2(2):109-116. doi: 10.1016/j.wjorl.2016.05.003. eCollection 2016 Jun.
Carcinoma of the head and neck represents 3.5% of all cancers, and the vast majority of these tumors are squamous cell carcinoma (HNSCC). With a stable overall survival rate of 50% among all stages, there is continued interested in developing measures for early detection and disease aggressiveness. Circulating tumor cells (CTCs) have been identified as a potential marker for early metastatic disease, response to treatment, and surveillance in head and neck squamous cell carcinoma. In this article, techniques of CTC detection, applications of CTC technology, and outcomes of HNSCC patients will be discussed.
头颈部癌占所有癌症的3.5%，其中绝大多数肿瘤为鳞状细胞癌（头颈部鳞状细胞癌）。所有阶段的总体生存率稳定在50%，因此人们持续关注开发早期检测和疾病侵袭性的措施。循环肿瘤细胞（CTC）已被确定为头颈部鳞状细胞癌早期转移性疾病、治疗反应和监测的潜在标志物。在本文中，将讨论CTC检测技术、CTC技术的应用以及头颈部鳞状细胞癌患者的治疗结果。
